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Recruitment and activation of a lipid kinase by Hepatitis C virus NS5A is essential for integrity of the membranous replication compartment

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Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To gain insight into host factor requirements for HCV replication, we performed a siRNA screen of the human kinome and identified 13 different kinases, including phosphatidylinositol-4 kinase III alpha (PI4KIIIα),...

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Main Authors: Reiss, Simon (Author) , Rebhan, Ilka (Author) , Backes, Perdita (Author) , Romero-Brey, Inés (Author) , Erfle, Holger (Author) , Matula, Petr (Author) , Kaderali, Lars (Author) , Pönisch, Marion (Author) , Blankenburg, Hagen (Author) , Hiet, Marie-Sophie (Author) , Longerich, Thomas (Author) , Diehl, Sarah (Author) , Ramirez, Fidel (Author) , Balla, Tamas (Author) , Rohr, Karl (Author) , Kaul, Artur (Author) , Bühler, Sandra (Author) , Pepperkok, Rainer (Author) , Lengauer, Thomas (Author) , Albrecht, Mario (Author) , Eils, Roland (Author) , Schirmacher, Peter (Author) , Lohmann, Volker (Author) , Bartenschlager, Ralf (Author)
Format: Article (Journal)
Language:English
Published: 19 January 2011
In: Cell host and microbe
Year: 2011, Volume: 9, Issue: 1, Pages: 32-45
ISSN:1934-6069
DOI:10.1016/j.chom.2010.12.002
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.chom.2010.12.002
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1931312810004129
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Author Notes:Simon Reiss, Ilka Rebhan, Perdita Backes, Ines Romero-Brey, Holger Erfle, Petr Matula, Lars Kaderali, Marion Poenisch, Hagen Blankenburg, Marie-Sophie Hiet, Thomas Longerich, Sarah Diehl, Fidel Ramirez, Tamas Balla, Karl Rohr, Artur Kaul, Sandra Bühler, Rainer Pepperkok, Thomas Lengauer, Mario Albrecht, Roland Eils, Peter Schirmacher, Volker Lohmann, and Ralf Bartenschlager
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Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment by Rebhan, Ilka (Author) , Backes, Perdita (Author) , Romero-Brey, Inés (Author) , Erfle, Holger (Author) , Matula, Petr (Author) , Kaderali, Lars (Author) , Pönisch, Marion (Author) , Blankenburg, Hagen (Author) , Hiet, Marie-Sophie (Author) , Longerich, Thomas (Author) , Diehl, Sarah (Author) , Ramirez, Fidel (Author) , Balla, Tamas (Author) , Rohr, Karl (Author) , Kaul, Artur (Author) , Bühler, Sandra (Author) , Pepperkok, Rainer (Author) , Lengauer, Thomas (Author) , Albrecht, Mario (Author) , Eils, Roland (Author) , Schirmacher, Peter (Author) , Lohmann, Volker (Author) , Bartenschlager, Ralf (Author) ,


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