A hydrogel for adhesion prevention: characterization and efficacy study in a rabbit uterus model
Objective - Postoperative peritoneal adhesions following gynaecological surgery remain a clinically relevant problem. One approach to prevent adhesion formation is to apply physical barriers such as hydrogels. - Study design - A physically crosslinked polyvinyl alcohol and carboxymethylcellulose (PV...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
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| In: |
European journal of obstetrics & gynecology and reproductive biology
Year: 2011, Jahrgang: 158, Heft: 1, Pages: 67-71 |
| ISSN: | 1872-7654 |
| DOI: | 10.1016/j.ejogrb.2010.11.008 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejogrb.2010.11.008 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0301211510005567 
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| Verfasserangaben: | Sascha A. Müller, Christine Weis, Erich K. Odermatt, Hanns-Peter Knaebel, Moritz N. Wente |
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| 245 | 1 | 2 | |a A hydrogel for adhesion prevention |b characterization and efficacy study in a rabbit uterus model |c Sascha A. Müller, Christine Weis, Erich K. Odermatt, Hanns-Peter Knaebel, Moritz N. Wente |
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| 520 | |a Objective - Postoperative peritoneal adhesions following gynaecological surgery remain a clinically relevant problem. One approach to prevent adhesion formation is to apply physical barriers such as hydrogels. - Study design - A physically crosslinked polyvinyl alcohol and carboxymethylcellulose (PVA/CMC) hydrogel (A-Part) was characterized in vitro. Three different traumatization methods were evaluated in a rabbit uterine study. To determine its anti-adhesion efficacy, the hydrogel was first tested in an in vivo pilot study and then in a larger trial to compare it with icodextrin 4% solution (Adept®) and controls. - Results - Rheological measurements showed an increased elasticity of the hydrogel after freezing. In vivo experiments revealed a clear reduction in incidence, extent and severity of adhesions compared to the icodextrin 4% solution and the untreated control group. - Conclusions - These results warrant further investigation of the PVA/CMC A-Part hydrogel in clinical trials focused on gynaecological procedures. | ||
| 650 | 4 | |a Adhesion formation | |
| 650 | 4 | |a Adhesions | |
| 650 | 4 | |a Hydrogel | |
| 650 | 4 | |a Rabbit uterus horn model | |
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