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High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients

Background: High-risk human papillomaviruses (HR-HPVs) can be detected in a proportion of non-melanoma skin cancers. Data on prevalence are inconclusive, but are essential to estimate the relevance of HR-HPV, particularly with regard to prophylactic HPV vaccines for skin cancer prevention. Methods:...

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Main Authors: Reuschenbach, Miriam (Author) , Tran, Thuong Hien (Author) , Faulstich, F. (Author) , Hartschuh, Wolfgang (Author) , Vinokurova, S. (Author) , Kloor, Matthias (Author) , Krautkrämer, E. (Author) , Zeier, Martin (Author) , Knebel Doeberitz, Magnus von (Author) , Sommerer, Claudia (Author)
Format: Article (Journal)
Language:English
Published: 22 March 2011
In: British journal of cancer
Year: 2011, Volume: 104, Issue: 8, Pages: 1334-1341
ISSN:1532-1827
DOI:10.1038/bjc.2011.95
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bjc.2011.95
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bjc201195
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Author Notes:M. Reuschenbach, T. Tran, F. Faulstich, W. Hartschuh, S. Vinokurova, M. Kloor, E. Krautkrämer, M. Zeier, M. von Knebel Doeberitz and C. Sommerer
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Summary:Background: High-risk human papillomaviruses (HR-HPVs) can be detected in a proportion of non-melanoma skin cancers. Data on prevalence are inconclusive, but are essential to estimate the relevance of HR-HPV, particularly with regard to prophylactic HPV vaccines for skin cancer prevention. Methods: High-risk human papillomavirus DNA was investigated in 140 non-melanoma skin lesions from 54 immunocompetent patients and 33 immunosuppressed renal allograft recipients. Expression of p16INK4a, a marker for HR-HPV oncogene expression in the uterine cervix, and of p53 and pRB was evaluated immunohistochemically. Results: The highest prevalence of HR-HPV was found in squamous cell cancer (SCC) (46.2% (6 out of 13) in immunosuppressed and 23.5% (4 out of 17) in immunocompetent patients). High-risk human papillomavirus positivity was accompanied by diffuse p16INK4a expression in most SCC (P<0.001) and basal cell cancers (P=0.02), while almost all SCC in situ were p16INK4a positive irrespective of HR-HPV presence (P=0.66). Diffuse p16INK4a expression was associated with lack of pRB expression (P=0.001). p53 was strongly expressed in 40.0% (56 out of 140) of the lesions irrespective of HR-HPV presence. Conclusion: High-risk human papillomavirus can be detected in lesions of keratinised squamous epithelia. The association of HR-HPV with diffuse p16INK4a expression might indicate HR-HPV oncogene expression in a proportion of lesions. Overexpression of p53 suggests p53 pathway alterations in HR-HPV-positive and -negative lesions.
Item Description:Gesehen am 15.09.2022
Physical Description:Online Resource
ISSN:1532-1827
DOI:10.1038/bjc.2011.95

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