High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients
Background: High-risk human papillomaviruses (HR-HPVs) can be detected in a proportion of non-melanoma skin cancers. Data on prevalence are inconclusive, but are essential to estimate the relevance of HR-HPV, particularly with regard to prophylactic HPV vaccines for skin cancer prevention. Methods:...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 March 2011
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| In: |
British journal of cancer
Year: 2011, Jahrgang: 104, Heft: 8, Pages: 1334-1341 |
| ISSN: | 1532-1827 |
| DOI: | 10.1038/bjc.2011.95 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bjc.2011.95 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bjc201195 
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| Verfasserangaben: | M. Reuschenbach, T. Tran, F. Faulstich, W. Hartschuh, S. Vinokurova, M. Kloor, E. Krautkrämer, M. Zeier, M. von Knebel Doeberitz and C. Sommerer |
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| 245 | 1 | 0 | |a High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients |c M. Reuschenbach, T. Tran, F. Faulstich, W. Hartschuh, S. Vinokurova, M. Kloor, E. Krautkrämer, M. Zeier, M. von Knebel Doeberitz and C. Sommerer |
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| 520 | |a Background: High-risk human papillomaviruses (HR-HPVs) can be detected in a proportion of non-melanoma skin cancers. Data on prevalence are inconclusive, but are essential to estimate the relevance of HR-HPV, particularly with regard to prophylactic HPV vaccines for skin cancer prevention. Methods: High-risk human papillomavirus DNA was investigated in 140 non-melanoma skin lesions from 54 immunocompetent patients and 33 immunosuppressed renal allograft recipients. Expression of p16INK4a, a marker for HR-HPV oncogene expression in the uterine cervix, and of p53 and pRB was evaluated immunohistochemically. Results: The highest prevalence of HR-HPV was found in squamous cell cancer (SCC) (46.2% (6 out of 13) in immunosuppressed and 23.5% (4 out of 17) in immunocompetent patients). High-risk human papillomavirus positivity was accompanied by diffuse p16INK4a expression in most SCC (P<0.001) and basal cell cancers (P=0.02), while almost all SCC in situ were p16INK4a positive irrespective of HR-HPV presence (P=0.66). Diffuse p16INK4a expression was associated with lack of pRB expression (P=0.001). p53 was strongly expressed in 40.0% (56 out of 140) of the lesions irrespective of HR-HPV presence. Conclusion: High-risk human papillomavirus can be detected in lesions of keratinised squamous epithelia. The association of HR-HPV with diffuse p16INK4a expression might indicate HR-HPV oncogene expression in a proportion of lesions. Overexpression of p53 suggests p53 pathway alterations in HR-HPV-positive and -negative lesions. | ||
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