Inhibin-betaC subunit expression in normal and pathological human placental tissues
Inhibins and activins are important regulators of the female reproductive system. Recently, a novel inhibin betaC subunit has been identified. However, only limited data on the expression of this novel inhibin-betaC subunit in normal and pathological human placentas exist. Tissue specimens of normal...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
|
| In: |
Systems biology in reproductive medicine
Year: 2011, Jahrgang: 57, Heft: 4, Pages: 197-203 |
| ISSN: | 1939-6376 |
| DOI: | 10.3109/19396368.2010.528505 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/19396368.2010.528505
|
| Verfasserangaben: | Ioannis Mylonas, Josef Makovitzky, Susanne Kunze, Ansgar Brüning, Franz Kainer, and Barbara Schiessl |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1816714402 | ||
| 003 | DE-627 | ||
| 005 | 20230710114948.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220915s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3109/19396368.2010.528505 |2 doi | |
| 035 | |a (DE-627)1816714402 | ||
| 035 | |a (DE-599)KXP1816714402 | ||
| 035 | |a (OCoLC)1389790029 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mylonas, Ioannis |d 1974- |e VerfasserIn |0 (DE-588)124220231 |0 (DE-627)085716359 |0 (DE-576)186705603 |4 aut | |
| 245 | 1 | 0 | |a Inhibin-betaC subunit expression in normal and pathological human placental tissues |c Ioannis Mylonas, Josef Makovitzky, Susanne Kunze, Ansgar Brüning, Franz Kainer, and Barbara Schiessl |
| 264 | 1 | |c 2011 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a First published online: 30 Nov 2010 | ||
| 500 | |a Gesehen am 15.09.2022 | ||
| 520 | |a Inhibins and activins are important regulators of the female reproductive system. Recently, a novel inhibin betaC subunit has been identified. However, only limited data on the expression of this novel inhibin-betaC subunit in normal and pathological human placentas exist. Tissue specimens of normal, preeclamptic, hemolysis, elevated liver enzymes, low platelets (HELLP), and intrauterine growth restriction (IUGR) pregnancies (n = 24) were obtained at the conclusion of a cesarean section. Normal and pathological placental tissues were analyzed by an immunohistochemical staining reaction with a specific antibody against this novel inhibin-betaC subunit. Overall, expression of the inhibin-betaC subunit could be demonstrated in normal and pathological placental tissue. The immunoreactive score (IRS) for inhibin-betaC did not show any significant differences between normal, preeclamptic, HELLP, and IUGR tissue in extravillous trophoblast and syncytiotrophoblast cells. Immunolabelling of this novel inhibin-βC protein in normal and pathological placental tissue was demonstrated, although no differences in the staining intensity could be observed. Therefore, the inhibin-βC isoform might not primarily be involved in the pathogenesis of these pregnancy-associated disorders. The functional role of this novel inhibin-betaC subunit in normal and pathological human placenta is still quite unclear and should thus be further investigated. | ||
| 650 | 4 | |a HELLP syndrome | |
| 650 | 4 | |a immunohistochemistry | |
| 650 | 4 | |a inhibin-betaC | |
| 650 | 4 | |a IUGR | |
| 650 | 4 | |a placenta | |
| 650 | 4 | |a preeclampsia | |
| 700 | 1 | |a Makovitzky, József |d 1942- |e VerfasserIn |0 (DE-588)1030495130 |0 (DE-627)735332622 |0 (DE-576)378344285 |4 aut | |
| 700 | 1 | |a Kunze, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brüning, Ansgar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kainer, Franz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schiessl, Barbara |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Systems biology in reproductive medicine |d Abingdon : Taylor & Francis Group, 2008 |g 57(2011), 4, Seite 197-203 |h Online-Ressource |w (DE-627)559429282 |w (DE-600)2412822-3 |w (DE-576)277981751 |x 1939-6376 |7 nnas |a Inhibin-betaC subunit expression in normal and pathological human placental tissues |
| 773 | 1 | 8 | |g volume:57 |g year:2011 |g number:4 |g pages:197-203 |g extent:7 |a Inhibin-betaC subunit expression in normal and pathological human placental tissues |
| 856 | 4 | 0 | |u https://doi.org/10.3109/19396368.2010.528505 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220915 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1030495130 |a Makovitzky, József |m 1030495130:Makovitzky, József |p 2 | ||
| 999 | |a KXP-PPN1816714402 |e 418883949X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Inhibin-betaC subunit expression in normal and pathological human placental tissues","title":"Inhibin-betaC subunit expression in normal and pathological human placental tissues"}],"person":[{"display":"Mylonas, Ioannis","roleDisplay":"VerfasserIn","role":"aut","family":"Mylonas","given":"Ioannis"},{"given":"József","family":"Makovitzky","role":"aut","roleDisplay":"VerfasserIn","display":"Makovitzky, József"},{"display":"Kunze, Susanne","roleDisplay":"VerfasserIn","role":"aut","family":"Kunze","given":"Susanne"},{"role":"aut","display":"Brüning, Ansgar","roleDisplay":"VerfasserIn","given":"Ansgar","family":"Brüning"},{"display":"Kainer, Franz","roleDisplay":"VerfasserIn","role":"aut","family":"Kainer","given":"Franz"},{"display":"Schiessl, Barbara","roleDisplay":"VerfasserIn","role":"aut","family":"Schiessl","given":"Barbara"}],"recId":"1816714402","language":["eng"],"note":["First published online: 30 Nov 2010","Gesehen am 15.09.2022"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.3109/19396368.2010.528505"],"eki":["1816714402"]},"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"2011"}],"name":{"displayForm":["Ioannis Mylonas, Josef Makovitzky, Susanne Kunze, Ansgar Brüning, Franz Kainer, and Barbara Schiessl"]},"relHost":[{"origin":[{"dateIssuedDisp":"2008-","publisher":"Taylor & Francis Group ; Informa Healthcare","dateIssuedKey":"2008","publisherPlace":"Abingdon ; London [u.a.]"}],"id":{"eki":["559429282"],"zdb":["2412822-3"],"issn":["1939-6376"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Systems biology in reproductive medicine","subtitle":"SBiRM","title_sort":"Systems biology in reproductive medicine"}],"disp":"Inhibin-betaC subunit expression in normal and pathological human placental tissuesSystems biology in reproductive medicine","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 11.12.23"],"language":["eng"],"recId":"559429282","pubHistory":["54.2008 -"],"titleAlt":[{"title":"SBiRM"}],"part":{"text":"57(2011), 4, Seite 197-203","volume":"57","extent":"7","year":"2011","issue":"4","pages":"197-203"}}],"physDesc":[{"extent":"7 S."}]} | ||
| SRT | |a MYLONASIOAINHIBINBET2011 | ||