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Clinical predictors of response and remission in inpatients with depressive syndromes

Background - Most predictor analyses search for single predictors or rely on data from randomized controlled trials. We aimed at detecting a set of clinical baseline variables for prediction of response and remission in 1014 naturalistically treated inpatients with major depressive episode treated f...

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Hauptverfasser: Riedel, Michael (VerfasserIn) , Möller, Hans-Jürgen (VerfasserIn) , Obermeier, Michael (VerfasserIn) , Adli, Mazda (VerfasserIn) , Bauer, Michael (VerfasserIn) , Kronmüller, Klaus-Thomas (VerfasserIn) , Brieger, Peter (VerfasserIn) , Laux, Gerd (VerfasserIn) , Bender, Wolfram (VerfasserIn) , Heuser, Isabella (VerfasserIn) , Zeiler, Joachim (VerfasserIn) , Gaebel, Wolfgang (VerfasserIn) , Schennach-Wolff, Rebecca (VerfasserIn) , Henkel, Verena (VerfasserIn) , Seemüller, Florian (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 8 May 2011
In: Journal of affective disorders
Year: 2011, Jahrgang: 133, Heft: 1-2, Pages: 137-149
ISSN:1573-2517
DOI:10.1016/j.jad.2011.04.007
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jad.2011.04.007
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165032711001595
Volltext
Verfasserangaben:Michael Riedel, Hans-Jürgen Möller, Michael Obermeier, Mazda Adli, Michael Bauer, Klaus Kronmüller, Peter Brieger, Gerd Laux, Wolfram Bender, Isabella Heuser, Joachim Zeiler, Wolfgang Gaebel, Rebecca Schennach-Wolff, Verena Henkel, Florian Seemüller
Beschreibung
Zusammenfassung:Background - Most predictor analyses search for single predictors or rely on data from randomized controlled trials. We aimed at detecting a set of clinical baseline variables for prediction of response and remission in 1014 naturalistically treated inpatients with major depressive episode treated for 53.62±47.5days. - Methods - A three-staged procedure was implemented. First, univariate tests were used for finding associations with baseline variables. Second, logistic regression and third-CART analyses were used to determine predictors of response to inpatient treatment. - Results - Presence of suicidality, a higher initial HAMD-21 total score, an episode length<24months, fewer previous hospitalizations, and absence of any ICD-10F4 comorbidity predicted response in 2 different statistical models. Remission was predicted by lower HAMD-21 baseline score, episode length<24months and fewer previous hospitalizations in both models. - Limitation - Results were assessed by a post-hoc analysis, based on prospectively collected data. No controlled study design. - Conclusion - Contrary to current beliefs, baseline suicidality might be associated with higher chances for response. In addition, baseline severity might impact outcome depending on which criterion (remission or response) used.
Beschreibung:Gesehen am 15.09.2022
Beschreibung:Online Resource
ISSN:1573-2517
DOI:10.1016/j.jad.2011.04.007

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