Combined DNA damage repair interference and ion beam therapy: development, benchmark, and clinical implications of a mechanistic biological model
Purpose - Our purpose was to develop a mechanistic model that describes and predicts radiation response after combined DNA damage repair interference (DDRi) and particle radiation therapy. - Methods and Materials - The heterogeneous dose distributions of protons and 4He ions were implemented into th...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2022
|
| In: |
International journal of radiation oncology, biology, physics
Year: 2022, Jahrgang: 112, Heft: 3, Pages: 802-817 |
| ISSN: | 1879-355X |
| DOI: | 10.1016/j.ijrobp.2021.09.048 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2021.09.048 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0360301621028662 
|
| Verfasserangaben: | Hans Liew, MSc, Sarah Meister, MSc, Stewart Mein, PhD, Thomas Tessonnier, PhD, Benedikt Kopp, MSc, Thomas Held, MD, Thomas Haberer, PhD, Amir Abdollahi, MD, PhD, Jürgen Debus, MD, PhD, Ivana Dokic, PhD, and Andrea Mairani, PhD |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1816777455 | ||
| 003 | DE-627 | ||
| 005 | 20240417193541.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220916s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijrobp.2021.09.048 |2 doi | |
| 035 | |a (DE-627)1816777455 | ||
| 035 | |a (DE-599)KXP1816777455 | ||
| 035 | |a (OCoLC)1361696068 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Liew, Hans |d 1994- |e VerfasserIn |0 (DE-588)1197708936 |0 (DE-627)1679441264 |4 aut | |
| 245 | 1 | 0 | |a Combined DNA damage repair interference and ion beam therapy |b development, benchmark, and clinical implications of a mechanistic biological model |c Hans Liew, MSc, Sarah Meister, MSc, Stewart Mein, PhD, Thomas Tessonnier, PhD, Benedikt Kopp, MSc, Thomas Held, MD, Thomas Haberer, PhD, Amir Abdollahi, MD, PhD, Jürgen Debus, MD, PhD, Ivana Dokic, PhD, and Andrea Mairani, PhD |
| 264 | 1 | |c 2022 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 25 October 2021 | ||
| 500 | |a Gesehen am 16.09.2022 | ||
| 520 | |a Purpose - Our purpose was to develop a mechanistic model that describes and predicts radiation response after combined DNA damage repair interference (DDRi) and particle radiation therapy. - Methods and Materials - The heterogeneous dose distributions of protons and 4He ions were implemented into the “UNIfied and VERSatile bio-response Engine” (UNIVERSE). Predictions for monoenergetic and mixed fields over clinically relevant dose and linear energy transfer range were compared with experimental in vitro survival data measured in this work as well as data available in the literature, including different cell lines and DDR interferences. Ultimately, UNIVERSE predictions were investigated in a patient plan. - Results - UNIVERSE accurately predicts survival of cell lines with and without DDRi in clinical settings of ion beam therapy based only on 3 parameters derived from photon data. With increasing dose or linear energy transfer, the radiosensitizing effect of DDRi decreases, resulting in diminished relative biological effect of ion beam radiation for cells subjected to DDRi in comparison to cells that are not. Similar trends were observed in patient plan recalculations; however, this analysis also suggests that DDRi + particle radiation therapy may better preserve the therapeutic window in comparison to DDRi + photon radiation therapy. - Conclusions - The presented framework represents the first mechanistic model of combined DDRi and particle radiation therapy comprehensively benchmarked in clinically relevant scenarios and a step toward more personalized treatment. It reveals potential differences between DDRi + photon radiation therapy versus DDRi + particle radiation therapy, which have not been described so far. UNIVERSE could aid in appraising the clinical viability of combined administration of radiosensitizing drugs and charged particle therapy, as well as the identification of patients with known DDR deficiencies in the tumor who might benefit from therapy with light ions, freeing limited space at heavy ion therapy centers. | ||
| 700 | 1 | |a Meister, Sarah |d 1992- |e VerfasserIn |0 (DE-588)1191424847 |0 (DE-627)1670071618 |4 aut | |
| 700 | 1 | |a Mein, Stewart |d 1989- |e VerfasserIn |0 (DE-588)1156925304 |0 (DE-627)1019871873 |0 (DE-576)502506105 |4 aut | |
| 700 | 1 | |a Tessonnier, Thomas |e VerfasserIn |0 (DE-588)1075079195 |0 (DE-627)83292685X |0 (DE-576)443252270 |4 aut | |
| 700 | 1 | |a Kopp, Benedikt |d 1990- |e VerfasserIn |0 (DE-588)1170097081 |0 (DE-627)1037079787 |0 (DE-576)512373809 |4 aut | |
| 700 | 1 | |a Held, Thomas |d 1990- |e VerfasserIn |0 (DE-588)1172053723 |0 (DE-627)104086970X |0 (DE-576)513977627 |4 aut | |
| 700 | 1 | |a Haberer, Thomas |d 1960- |e VerfasserIn |0 (DE-588)123579198 |0 (DE-627)706353714 |0 (DE-576)214902188 |4 aut | |
| 700 | 1 | |a Abdollahi, Amir |e VerfasserIn |0 (DE-588)129612715 |0 (DE-627)474757765 |0 (DE-576)297748874 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Dokić, Ivana |e VerfasserIn |0 (DE-588)1024109208 |0 (DE-627)719434378 |0 (DE-576)367945789 |4 aut | |
| 700 | 1 | |a Mairani, Andrea |e VerfasserIn |0 (DE-588)1116742179 |0 (DE-627)870669281 |0 (DE-576)478592493 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of radiation oncology, biology, physics |d Amsterdam [u.a.] : Elsevier Science, 1975 |g 112(2022), 3 vom: 1. März, Seite 802-817 |h Online-Ressource |w (DE-627)306659662 |w (DE-600)1500486-7 |w (DE-576)081986319 |x 1879-355X |7 nnas |a Combined DNA damage repair interference and ion beam therapy development, benchmark, and clinical implications of a mechanistic biological model |
| 773 | 1 | 8 | |g volume:112 |g year:2022 |g number:3 |g day:1 |g month:03 |g pages:802-817 |g extent:16 |a Combined DNA damage repair interference and ion beam therapy development, benchmark, and clinical implications of a mechanistic biological model |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijrobp.2021.09.048 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0360301621028662 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220916 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1191424847 |a Meister, Sarah |m 1191424847:Meister, Sarah |d 140000 |e 140000PM1191424847 |k 0/140000/ |p 2 | ||
| 998 | |g 1116742179 |a Mairani, Andrea |m 1116742179:Mairani, Andrea |d 50000 |e 50000PM1116742179 |k 0/50000/ |p 11 |y j | ||
| 998 | |g 1024109208 |a Dokić, Ivana |m 1024109208:Dokić, Ivana |d 50000 |e 50000PD1024109208 |k 0/50000/ |p 10 | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 9 | ||
| 998 | |g 129612715 |a Abdollahi, Amir |m 129612715:Abdollahi, Amir |d 910000 |d 911400 |e 910000PA129612715 |e 911400PA129612715 |k 0/910000/ |k 1/910000/911400/ |p 8 | ||
| 998 | |g 1075079195 |a Tessonnier, Thomas |m 1075079195:Tessonnier, Thomas |d 910000 |d 950000 |d 950400 |e 910000PT1075079195 |e 950000PT1075079195 |e 950400PT1075079195 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950400/ |p 4 | ||
| 998 | |g 1156925304 |a Mein, Stewart |m 1156925304:Mein, Stewart |d 910000 |d 950000 |d 950400 |e 910000PM1156925304 |e 950000PM1156925304 |e 950400PM1156925304 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950400/ |p 3 | ||
| 998 | |g 123579198 |a Haberer, Thomas |m 123579198:Haberer, Thomas |d 910000 |d 950000 |d 950400 |e 910000PH123579198 |e 950000PH123579198 |e 950400PH123579198 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950400/ |p 7 | ||
| 998 | |g 1172053723 |a Held, Thomas |m 1172053723:Held, Thomas |d 910000 |d 911400 |e 910000PH1172053723 |e 911400PH1172053723 |k 0/910000/ |k 1/910000/911400/ |p 6 | ||
| 998 | |g 1170097081 |a Kopp, Benedikt |m 1170097081:Kopp, Benedikt |d 910000 |d 911400 |e 910000PK1170097081 |e 911400PK1170097081 |k 0/910000/ |k 1/910000/911400/ |p 5 | ||
| 998 | |g 1197708936 |a Liew, Hans |m 1197708936:Liew, Hans |d 130000 |e 130000PL1197708936 |k 0/130000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1816777455 |e 4189297046 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Hans Liew, MSc, Sarah Meister, MSc, Stewart Mein, PhD, Thomas Tessonnier, PhD, Benedikt Kopp, MSc, Thomas Held, MD, Thomas Haberer, PhD, Amir Abdollahi, MD, PhD, Jürgen Debus, MD, PhD, Ivana Dokic, PhD, and Andrea Mairani, PhD"]},"id":{"eki":["1816777455"],"doi":["10.1016/j.ijrobp.2021.09.048"]},"recId":"1816777455","physDesc":[{"extent":"16 S."}],"person":[{"display":"Liew, Hans","given":"Hans","role":"aut","family":"Liew"},{"display":"Meister, Sarah","given":"Sarah","role":"aut","family":"Meister"},{"role":"aut","given":"Stewart","family":"Mein","display":"Mein, Stewart"},{"given":"Thomas","role":"aut","family":"Tessonnier","display":"Tessonnier, Thomas"},{"display":"Kopp, Benedikt","family":"Kopp","role":"aut","given":"Benedikt"},{"family":"Held","role":"aut","given":"Thomas","display":"Held, Thomas"},{"given":"Thomas","role":"aut","family":"Haberer","display":"Haberer, Thomas"},{"display":"Abdollahi, Amir","given":"Amir","role":"aut","family":"Abdollahi"},{"family":"Debus","role":"aut","given":"Jürgen","display":"Debus, Jürgen"},{"display":"Dokić, Ivana","family":"Dokić","given":"Ivana","role":"aut"},{"family":"Mairani","role":"aut","given":"Andrea","display":"Mairani, Andrea"}],"relHost":[{"note":["Gesehen am 15.01.20","Ungezählte Beil.: Supplement"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"part":{"pages":"802-817","text":"112(2022), 3 vom: 1. März, Seite 802-817","extent":"16","issue":"3","year":"2022","volume":"112"},"title":[{"title":"International journal of radiation oncology, biology, physics","title_sort":"International journal of radiation oncology, biology, physics","subtitle":"the official journal of the American Society for Therapeutic Radiology and Oncology"}],"id":{"zdb":["1500486-7"],"eki":["306659662"],"issn":["1879-355X"]},"pubHistory":["1.1975/76 -"],"origin":[{"publisher":"Elsevier Science","dateIssuedKey":"1975","dateIssuedDisp":"1975-","publisherPlace":"Amsterdam [u.a.]"}],"disp":"Combined DNA damage repair interference and ion beam therapy development, benchmark, and clinical implications of a mechanistic biological modelInternational journal of radiation oncology, biology, physics","physDesc":[{"extent":"Online-Ressource"}],"recId":"306659662"}],"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"2022"}],"title":[{"title_sort":"Combined DNA damage repair interference and ion beam therapy","title":"Combined DNA damage repair interference and ion beam therapy","subtitle":"development, benchmark, and clinical implications of a mechanistic biological model"}],"note":["Available online 25 October 2021","Gesehen am 16.09.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"]} | ||
| SRT | |a LIEWHANSMECOMBINEDDN2022 | ||