Humoral and cellular responses after COVID-19 vaccination in anti-CD20-treated lymphoma patients
TO THE EDITOR:Patients with hematological neoplasms, including lymphoma patients, have a high risk for severe COVID-19 diseases.1-4 COVID-19 vaccinations induce strong serologic and T-cell responses in immunocompetent humans and thereby effectively prevent severe COVID-19 disease courses.5-8 There i...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
2022
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| In: |
Blood
Year: 2022, Volume: 139, Issue: 1, Pages: 142-147 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood.2021013445 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.2021013445 |
| Author Notes: | Nora Liebers, Claudius Speer, Louise Benning, Peter-Martin Bruch, Isabelle Kraemer, Julia Meissner, Paul Schnitzler, Hans-Georg Kräusslich, Peter Dreger, Carsten Mueller-Tidow, Isabel Poschke, and Sascha Dietrich |
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| 520 | |a TO THE EDITOR:Patients with hematological neoplasms, including lymphoma patients, have a high risk for severe COVID-19 diseases.1-4 COVID-19 vaccinations induce strong serologic and T-cell responses in immunocompetent humans and thereby effectively prevent severe COVID-19 disease courses.5-8 There is accumulating evidence that humoral immune responses after vaccination are impaired in patients with hematological malignancies, especially if they were treated with B-cell-depleting therapies such as anti-CD20 antibodies.9-11 However, there is limited information about the T-cell-mediated vaccine responses after anti-CD20 treatment. In this study, we investigated the humoral and cellular responses after COVID-19 vaccination in lymphoma patients who had received anti-CD20 treatment. | ||
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