Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin
Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four week...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 April 2011
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| In: |
Immunobiology
Year: 2011, Volume: 216, Issue: 10, Pages: 1127-1134 |
| ISSN: | 1878-3279 |
| DOI: | 10.1016/j.imbio.2011.04.004 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.imbio.2011.04.004 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0171298511000751 
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| Author Notes: | Pedro N. Rodrigues, Sandro S. Gomes, João V. Neves, Sandra Gomes-Pereira, Margarida Correia-Neves, Cláudio Nunes-Alves, Jens Stolte, Mayka Sanchez, Rui Appelberg, Martina U. Muckenthaler, M. Salomé Gomes |
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| 245 | 1 | 0 | |a Mycobacteria-induced anaemia revisited |b a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin |c Pedro N. Rodrigues, Sandro S. Gomes, João V. Neves, Sandra Gomes-Pereira, Margarida Correia-Neves, Cláudio Nunes-Alves, Jens Stolte, Mayka Sanchez, Rui Appelberg, Martina U. Muckenthaler, M. Salomé Gomes |
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| 520 | |a Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four weeks after infection with Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by an increase on hepatic hepcidin mRNA expression. Instead, infected mice presented increased mRNA expression of ferroportin (Slc40a1), ceruloplasmin (Cp), hemopexin (Hpx), heme-oxygenase-1 (Hmox1) and lipocalin-2 (Lcn2). Both the anaemia and the mRNA expression changes of iron-related genes were largely absent in C.D2 mice which bear a functional allele of the Nramp1 gene. Data presented in this work suggest that anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin expression, is influenced by Nramp1 and may involve lipocalin-2. | ||
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