S100A1 gene therapy for heart failure: A novel strategy on the verge of clinical trials
Representing the common endpoint of various cardiovascular disorders, heart failure (HF) shows a dramatically growing prevalence. As currently available therapeutic strategies are not capable of terminating the progress of the disease, HF is still associated with a poor clinical prognosis. Among the...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
|
| In: |
Journal of molecular and cellular cardiology
Year: 2011, Jahrgang: 50, Heft: 5, Pages: 777-784 |
| ISSN: | 1095-8584 |
| DOI: | 10.1016/j.yjmcc.2010.08.012 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.yjmcc.2010.08.012 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022282810002993 
|
| Verfasserangaben: | David Rohde, Henriette Brinks, Julia Ritterhoff, Gang Qui, Shumei Ren, Patrick Most |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1816934895 | ||
| 003 | DE-627 | ||
| 005 | 20230710114552.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220919s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.yjmcc.2010.08.012 |2 doi | |
| 035 | |a (DE-627)1816934895 | ||
| 035 | |a (DE-599)KXP1816934895 | ||
| 035 | |a (OCoLC)1389788046 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rohde, David |d 1981- |e VerfasserIn |0 (DE-588)1025512685 |0 (DE-627)722472846 |0 (DE-576)370430999 |4 aut | |
| 245 | 1 | 0 | |a S100A1 gene therapy for heart failure |b A novel strategy on the verge of clinical trials |c David Rohde, Henriette Brinks, Julia Ritterhoff, Gang Qui, Shumei Ren, Patrick Most |
| 246 | 3 | 0 | |a one |
| 264 | 1 | |c 2011 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 20 August 2010 | ||
| 500 | |a Gesehen am 19.09.2022 | ||
| 520 | |a Representing the common endpoint of various cardiovascular disorders, heart failure (HF) shows a dramatically growing prevalence. As currently available therapeutic strategies are not capable of terminating the progress of the disease, HF is still associated with a poor clinical prognosis. Among the underlying molecular mechanisms, the loss of cardiomyocyte Ca2+ cycling integrity plays a key role in the pathophysiological development and progression of the disease. The cardiomyocyte EF-hand Ca2+ sensor protein S100A1 emerged as a regulator both of sarcoplasmic reticulum (SR), sarcomere and mitochondrial function implicating a significant role in cardiac physiology and dysfunction. In this review, we aim to recapitulate the translation of S100A1-based investigation from first clinical observations over basic research experiments back to a near-clinical setting on the verge of clinical trials today. We also address needs for further developments towards “second-generation” gene therapy and discuss the therapeutic potential of S100A1 gene therapy for HF as a promising novel strategy for future cardiologists. This article is part of a Special Section entitled “Special Section: Cardiovascular Gene Therapy”. | ||
| 650 | 4 | |a Calcium | |
| 650 | 4 | |a Gene therapy | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Mitochondria | |
| 650 | 4 | |a Myofilaments | |
| 650 | 4 | |a Reticulum | |
| 650 | 4 | |a S100A1 | |
| 650 | 4 | |a Sarcoplasmic | |
| 700 | 1 | |a Brinks, Henriette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ritterhoff, Julia |e VerfasserIn |0 (DE-588)1043976426 |0 (DE-627)771174101 |0 (DE-576)396460941 |4 aut | |
| 700 | 1 | |a Qui, Gang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ren, Shumei |e VerfasserIn |4 aut | |
| 700 | 1 | |a Most, Patrick |d 1969- |e VerfasserIn |0 (DE-588)124606431 |0 (DE-627)363440267 |0 (DE-576)29440919X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of molecular and cellular cardiology |d New York, NY [u.a.] : Elsevier, 1970 |g 50(2011), 5, Seite 777-784 |h Online-Ressource |w (DE-627)267328095 |w (DE-600)1469767-1 |w (DE-576)104193913 |x 1095-8584 |7 nnas |a S100A1 gene therapy for heart failure A novel strategy on the verge of clinical trials |
| 773 | 1 | 8 | |g volume:50 |g year:2011 |g number:5 |g pages:777-784 |g extent:8 |a S100A1 gene therapy for heart failure A novel strategy on the verge of clinical trials |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.yjmcc.2010.08.012 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0022282810002993 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220919 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 124606431 |a Most, Patrick |m 124606431:Most, Patrick |d 910000 |d 910100 |e 910000PM124606431 |e 910100PM124606431 |k 0/910000/ |k 1/910000/910100/ |p 6 |y j | ||
| 998 | |g 1043976426 |a Ritterhoff, Julia |m 1043976426:Ritterhoff, Julia |p 3 | ||
| 998 | |g 1025512685 |a Rohde, David |m 1025512685:Rohde, David |d 910000 |d 910100 |e 910000PR1025512685 |e 910100PR1025512685 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1816934895 |e 4189967890 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","given":"David","family":"Rohde","display":"Rohde, David"},{"given":"Henriette","role":"aut","family":"Brinks","display":"Brinks, Henriette"},{"family":"Ritterhoff","display":"Ritterhoff, Julia","given":"Julia","role":"aut"},{"given":"Gang","role":"aut","display":"Qui, Gang","family":"Qui"},{"role":"aut","given":"Shumei","display":"Ren, Shumei","family":"Ren"},{"role":"aut","given":"Patrick","family":"Most","display":"Most, Patrick"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"2011","dateIssuedKey":"2011"}],"note":["Available online 20 August 2010","Gesehen am 19.09.2022"],"title":[{"subtitle":"A novel strategy on the verge of clinical trials","title_sort":"S100A1 gene therapy for heart failure","title":"S100A1 gene therapy for heart failure"}],"id":{"doi":["10.1016/j.yjmcc.2010.08.012"],"eki":["1816934895"]},"recId":"1816934895","relHost":[{"corporate":[{"role":"isb","display":"International Society for Heart Research"}],"language":["eng"],"part":{"volume":"50","extent":"8","issue":"5","text":"50(2011), 5, Seite 777-784","pages":"777-784","year":"2011"},"title":[{"title":"Journal of molecular and cellular cardiology","title_sort":"Journal of molecular and cellular cardiology"}],"pubHistory":["1.1970 -"],"origin":[{"dateIssuedDisp":"1970-","publisher":"Elsevier ; Academic Press","dateIssuedKey":"1970","publisherPlace":"New York, NY [u.a.] ; London"}],"note":["Gesehen am 21.01.20","Ungezählte Beil.: Supplement"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"S100A1 gene therapy for heart failure A novel strategy on the verge of clinical trialsJournal of molecular and cellular cardiology","recId":"267328095","physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["International Society for Heart Research"]},"id":{"eki":["267328095"],"zdb":["1469767-1"],"issn":["1095-8584"]}}],"name":{"displayForm":["David Rohde, Henriette Brinks, Julia Ritterhoff, Gang Qui, Shumei Ren, Patrick Most"]},"physDesc":[{"extent":"8 S."}]} | ||
| SRT | |a ROHDEDAVIDS100A1GENE2011 | ||