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Recent advances in “sickle and niche” research: tribute to Dr. Paul S Frenette

In this retrospective, we review the two research topics that formed the basis of the outstanding career of Dr. Paul S. Frenette. In the first part, we focus on sickle cell disease (SCD). The defining feature of SCD is polymerization of the deoxygenated mutant hemoglobin, which leads to a vicious cycl...

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Main Authors: Torres, Lidiane S. (Author) , Asada, Noboru (Author) , Weiss, Mitchell J. (Author) , Trumpp, Andreas (Author) , Suda, Toshio (Author) , Scadden, David T. (Author) , Ito, Keisuke (Author)
Format: Article (Journal) Festschrift
Language:English
Published: 12 July 2022
In: Stem cell reports
Year: 2022, Volume: 17, Issue: 7, Pages: 1509-1535
ISSN:2213-6711
DOI:10.1016/j.stemcr.2022.06.004
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Festschrift
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.stemcr.2022.06.004
Verlag, kostenfrei, Volltext: https://linkinghub.elsevier.com/retrieve/pii/S2213671122003204
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Author Notes:Lidiane S. Torres, Noboru Asada, Mitchell J. Weiss, Andreas Trumpp, Toshio Suda, David T. Scadden, and Keisuke Ito
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Summary:In this retrospective, we review the two research topics that formed the basis of the outstanding career of Dr. Paul S. Frenette. In the first part, we focus on sickle cell disease (SCD). The defining feature of SCD is polymerization of the deoxygenated mutant hemoglobin, which leads to a vicious cycle of hemolysis and vaso-occlusion. We survey important discoveries in SCD pathophysiology that have led to recent advances in treatment of SCD. The second part focuses on the hematopoietic stem cell (HSC) niche, the complex microenvironment within the bone marrow that controls HSC function and homeostasis. We detail the cells that constitute this niche, and the factors that these cells use to exert control over hematopoiesis. Here, we trace the scientific paths of Dr. Frenette, highlight key aspects of his research, and identify his most important scientific contributions in both fields.
Item Description:Gesehen am 20.09.2022
Physical Description:Online Resource
ISSN:2213-6711
DOI:10.1016/j.stemcr.2022.06.004

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