Directional switching of the kinesin Cin8 through motor coupling
Kinesin motor proteins are thought to move exclusively in either one or the other direction along microtubules. Proteins of the kinesin-5 family are tetrameric microtubule cross-linking motors important for cell division and differentiation in various organisms. Kinesin-5 motors are considered to be...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 February 2011
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| In: |
Science
Year: 2011, Jahrgang: 332, Heft: 6025, Pages: 94-99 |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.1199945 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.1199945 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/science.1199945 
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| Verfasserangaben: | Johanna Roostalu, Christian Hentrich, Peter Bieling, Ivo A. Telley, Elmar Schiebel, Thomas Surrey |
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| 520 | |a Kinesin motor proteins are thought to move exclusively in either one or the other direction along microtubules. Proteins of the kinesin-5 family are tetrameric microtubule cross-linking motors important for cell division and differentiation in various organisms. Kinesin-5 motors are considered to be plus-end–directed. However, here we found that purified kinesin-5 Cin8 from budding yeast could behave as a bidirectional kinesin. On individual microtubules, single Cin8 motors were minus-end–directed motors, whereas they switched to plus-end–directed motility when working in a team of motors sliding antiparallel microtubules apart. This kinesin can thus change directionality of movement depending on whether it acts alone or in an ensemble. | ||
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