Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance
The discovery how Cdk1 kinase is recruited to centrosomes advances understanding of how mitosis is controlled and why centrosome amplification and chromosomal breakage occur so commonly in cancer cells.
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
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| In: |
Cancer research
Year: 2011, Jahrgang: 71, Heft: 6, Pages: 2129-2139 |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-10-2684 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-10-2684 Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/cancerres/article/71/6/2129/570389/Cep63-Recruits-Cdk1-to-the-Centrosome-Implications |
| Verfasserangaben: | Harald Löffler, Anne Fechter, Marc Matuszewska, Rainer Saffrich, Martin Mistrik, Joachim Marhold, Christin Hornung, Frank Westermann, Jiri Bartek, and Alwin Krämer |
| Zusammenfassung: | The discovery how Cdk1 kinase is recruited to centrosomes advances understanding of how mitosis is controlled and why centrosome amplification and chromosomal breakage occur so commonly in cancer cells. |
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| Beschreibung: | Gesehen am 20.09.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1538-7445 |
| DOI: | 10.1158/0008-5472.CAN-10-2684 |