In PSC with Colitis treated with UDCA, most colonic carcinomas develop in the first years after the start of treatment
Background: Patients with PSC and IBD have a high incidence of colonic carcinomas (CRC), and the annual incidence of CRC increases with duration of disease. UDCA treatment has been suggested to reduce colonic dysplasias and carcinomas. Aims: The annual incidence of colorectal carcinomas after long-t...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
09 June 2011
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| In: |
Digestive diseases and sciences
Year: 2011, Volume: 56, Issue: 12, Pages: 3624-3630 |
| ISSN: | 1573-2568 |
| DOI: | 10.1007/s10620-011-1763-2 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10620-011-1763-2
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| Author Notes: | G. Rudolph, D.N. Gotthardt, P. Kloeters-Plachky, H. Kulaksiz, P. Schirmacher, A. Stiehl |
MARC
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| 520 | |a Background: Patients with PSC and IBD have a high incidence of colonic carcinomas (CRC), and the annual incidence of CRC increases with duration of disease. UDCA treatment has been suggested to reduce colonic dysplasias and carcinomas. Aims: The annual incidence of colorectal carcinomas after long-term UDCA treatment was studied. Methods: Patients included in a prospective study on the outcome after ursodeoxycholic acid (UDCA) treatment were evaluated. Results: A total of 120 of 171 PSC patients included had IBD (108 UC and 12 CD). All patients were treated with UDCA for a median time of 6.7 years. Seven patients with PSC and IBD developed a CRC yielding a prevalence of 5.8%. In years 0–3 (n = 120) after the start of UDCA, the annual incidence rate of CRC was 0.62/100 patient years; in years 3–6 (n = 93) it increased to 1.28 and decreased thereafter in years 6–9 (n = 67) to 1.17, then in years 9–12 (n = 42) to 0 and after >12 years (n = 24) it remained 0. In PSC with IBD, Kaplan–Meier estimate of CRC formation increased with time in the first years of treatment and reached a plateau after 9 years; after treatment for ≥9 years, no further CRC were observed. Conclusion: After the start of UDCA, the annual incidence of CRC increased up to 6 years and subsequently decreased. In PSC with IBD treated with UDCA, most colonic carcinomas develop in the first years after the start of treatment. | ||
| 650 | 4 | |a Colonic carcinomas | |
| 650 | 4 | |a Inflammatory bowel disease | |
| 650 | 4 | |a Sclerosing cholangitis | |
| 650 | 4 | |a Ursodeoxycholic acid | |
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