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Trailblazing precision medicine in Europe: A joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany

Over the last decades, rapid technological and scientific advances have led to a merge of molecular sciences and clinical medicine, resulting in a better understanding of disease mechanisms and the development of novel therapies that exploit specific molecular lesions or profiles driving disease. Pr...

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Main Authors: Stenzinger, Albrecht (Author) , Edsjö, Anders (Author) , Plöger, Carolin (Author) , Friedman, Mikaela (Author) , Fröhling, Stefan (Author) , Wirta, Valtteri (Author) , Seufferlein, Thomas (Author) , Botling, Johan (Author) , Duyster, Justus (Author) , Akhras, Michael (Author) , Thimme, Robert (Author) , Fioretos, Thoas (Author) , Bitzer, Michael (Author) , Cavelier, Lucia (Author) , Schirmacher, Peter (Author) , Malek, Nisar (Author) , Rosenquist, Richard (Author) , Lindstrand, Anna (Author) , Wedell, Anna (Author) , Gisselsson, David (Author) , Melén, Erik (Author) , Helenius, Gisela (Author) , Ehrencrona, Hans (Author) , Engstrand, Lars (Author) , Palmqvist, Lars (Author) , Levin, Lars-Åke (Author) , Lovmar, Lovisa (Author) , Landström, Maréne (Author) , Hallbeck, Martin (Author) , Wadelius, Mia (Author) , Sikora, Per (Author) , Beer, Ambros J. (Author) , Illert, Anna L. (Author) , Budczies, Jan (Author) , Nikolaou, Konstantin (Author) , Kohlbacher, Oliver (Author) , Horak, Peter (Author) , Kuhn, Peter (Author) , Schroeder, Christopher (Author) , Boerries, Melanie (Author) , Lassmann, Silke (Author) , Gaidzik, Verena I. (Author)
Format: Article (Journal)
Language:English
Published: 25 June 2022
In: Seminars in cancer biology
Year: 2022, Volume: 84, Pages: 242-254
ISSN:1096-3650
DOI:10.1016/j.semcancer.2021.05.026
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.semcancer.2021.05.026
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1044579X21001565
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Author Notes:Albrecht Stenzinger, Anders Edsjö, Carolin Ploeger, Mikaela Friedman, Stefan Fröhling, Valtteri Wirta, Thomas Seufferlein, Johan Botling, Justus Duyster, Michael Akhras, Robert Thimme, Thoas Fioretos, Michael Bitzer, Lucia Cavelier, Peter Schirmacher, Nisar Malek, Richard Rosenquist, on behalf of GMS working group and ZPM working group
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Summary:Over the last decades, rapid technological and scientific advances have led to a merge of molecular sciences and clinical medicine, resulting in a better understanding of disease mechanisms and the development of novel therapies that exploit specific molecular lesions or profiles driving disease. Precision oncology is here used as an example, illustrating the potential of precision/personalized medicine that also holds great promise in other medical fields. Real-world implementation can only be achieved by dedicated healthcare connected centers which amass and build up interdisciplinary expertise reflecting the complexity of precision medicine. Networks of such centers are ideally suited for a nation-wide outreach offering access to precision medicine to patients independent of their place of residence. Two of these multicentric initiatives, Genomic Medicine Sweden (GMS) and the Centers for Personalized Medicine (ZPM) initiative in Germany have teamed up to present and share their views on core concepts, potentials, challenges, and future developments in precision medicine. Together with other initiatives worldwide, GMS and ZPM aim at providing a robust and sustainable framework, covering all components from technology development to clinical trials, ethical and legal aspects as well as involvement of all relevant stakeholders, including patients and policymakers in the field.
Item Description:ZPM working group: Anna Lindstrand, Anna Wedell, David Gisselsson, Erik Melén, Gisela Helenius, Hans Ehrencrona, Lars Engstrand, Lars Palmqvist, Lars-Åke Levin, Lovisa Lovmar, Maréne Landström, Martin Hallbeck, Mia Wadelius, Per Sikora
GMS working group: Ambros J. Beer, Anna L. Illert, Jan Budczies, Konstantin Nikolaou, Oliver Kohlbacher, Peter Horak, Peter Kuhn, Christopher Schroeder, Melanie Boerries, Silke Lassmann, Verena I. Gaidzik
Gesehen am 21.09.2022
Physical Description:Online Resource
ISSN:1096-3650
DOI:10.1016/j.semcancer.2021.05.026

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