Blockade of leukocyte haptokinesis and haptotaxis by ketoprofen, diclofenac and SC-560
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID) represent a one of the most widely used anti-inflammatory substances. Their anti-inflammatory effects are mainly based on inhibition of cyclooxygenase. The potential direct effect of NSAID on leukocyte migration was poorly investigated. Using...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 November 2011
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| In: |
BMC immunology
Year: 2011, Jahrgang: 12, Pages: 1-9 |
| ISSN: | 1471-2172 |
| DOI: | 10.1186/1471-2172-12-64 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2172-12-64
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| Verfasserangaben: | Saulius Paskauskas, Audrius Parseliunas, Vachtang Kerkadze, Rainer Nobiling, Jan Schmidt and Eduard Ryschich |
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| 245 | 1 | 0 | |a Blockade of leukocyte haptokinesis and haptotaxis by ketoprofen, diclofenac and SC-560 |c Saulius Paskauskas, Audrius Parseliunas, Vachtang Kerkadze, Rainer Nobiling, Jan Schmidt and Eduard Ryschich |
| 264 | 1 | |c 12 November 2011 | |
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| 520 | |a BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID) represent a one of the most widely used anti-inflammatory substances. Their anti-inflammatory effects are mainly based on inhibition of cyclooxygenase. The potential direct effect of NSAID on leukocyte migration was poorly investigated. Using time-lapse microscopy and 96-well fluorescence-based assay, we studied the effect of three different NSAID, ketoprofen, diclofenac and SC-560, on leukocyte haptokinesis and haptotaxis in vivo and in vitro. - RESULTS: NSAID induced an immediate inhibiting effect on leukocyte migration both in vitro and in vivo. This effect was dose-dependent and was not restricted to a specific type of leukocytes. The inhibition of leukocyte migration by NSAID was partially re-stored after removal of inhibiting agent. Only complete blockade of leukocyte migration was accompanied by a strong reduction of [Ca(2+)]i. - CONCLUSIONS: NSAID strongly supress leukocyte migration. The results of the present study may have important clinical implications since blockade of leukocyte migration can be achieved after topical application of NSAID. | ||
| 650 | 4 | |a Anti-Inflammatory Agents, Non-Steroidal | |
| 650 | 4 | |a Calcium | |
| 650 | 4 | |a Cell Movement | |
| 650 | 4 | |a Cells, Cultured | |
| 650 | 4 | |a Chemotaxis | |
| 650 | 4 | |a Cyclooxygenase Inhibitors | |
| 650 | 4 | |a Diclofenac | |
| 650 | 4 | |a Dose-Response Relationship, Drug | |
| 650 | 4 | |a Enzyme Inhibitors | |
| 650 | 4 | |a Extracellular Matrix | |
| 650 | 4 | |a Haptens | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Ketoprofen | |
| 650 | 4 | |a Leukocytes, Mononuclear | |
| 650 | 4 | |a Pyrazoles | |
| 650 | 4 | |a Time-Lapse Imaging | |
| 700 | 1 | |a Parseliunas, Audrius |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kerkadze, Vachtang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nobiling, Rainer |e VerfasserIn |0 (DE-588)107676990X |0 (DE-627)835318249 |0 (DE-576)179265369 |4 aut | |
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| 700 | 1 | |a Ryschich, Eduard |d 1967- |e VerfasserIn |0 (DE-588)120246546 |0 (DE-627)696498340 |0 (DE-576)292118090 |4 aut | |
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