Effect of rifampicin and CYP2B6 genotype on long-term efavirenz autoinduction and plasma exposure in HIV patients with or without tuberculosis
We performed a prospective comparative study to examine, from a pharmacogenetics perspective, the effect of rifampicin (RIF) on long-term efavirenz (EFV) autoinduction and kinetics. In a study population of patients with HIV receiving EFV with RIF (arm 2, n = 54) or without RIF (arm 1, n = 128 contr...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
03 August 2011
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| In: |
Clinical pharmacology & therapeutics
Year: 2011, Volume: 90, Issue: 3, Pages: 406-413 |
| ISSN: | 1532-6535 |
| DOI: | 10.1038/clpt.2011.129 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/clpt.2011.129 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1038/clpt.2011.129 
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| Author Notes: | E Ngaimisi, S Mugusi, O Minzi, P Sasi, K-D Riedel, A Suda, N Ueda, M Janabi, F Mugusi, WE Haefeli, L Bertilsson, J Burhenne and E Aklillu |
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| 245 | 1 | 0 | |a Effect of rifampicin and CYP2B6 genotype on long-term efavirenz autoinduction and plasma exposure in HIV patients with or without tuberculosis |c E Ngaimisi, S Mugusi, O Minzi, P Sasi, K-D Riedel, A Suda, N Ueda, M Janabi, F Mugusi, WE Haefeli, L Bertilsson, J Burhenne and E Aklillu |
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| 520 | |a We performed a prospective comparative study to examine, from a pharmacogenetics perspective, the effect of rifampicin (RIF) on long-term efavirenz (EFV) autoinduction and kinetics. In a study population of patients with HIV receiving EFV with RIF (arm 2, n = 54) or without RIF (arm 1, n = 128 controls), intraindividual and interindividual plasma EFV and 8-hydroxyefavirenz levels were compared at weeks 4 and 16 of EFV therapy. In arm 2, RIF was initiated 4 weeks before starting EFV. In controls (arm 1), the plasma EFV was significantly lower whereas 8-hydroxyefavirenz was higher at week 16 as compared to week 4. By contrast, there were no significant differences in plasma EFV and 8-hydroxyefavirenz concentrations over time in arm 2. At week 4, the plasma EFV concentration was significantly lower in arm 2 as compared to arm 1, but no significant differences were observed by week 16. When stratified by CYP2B6 genotype, significant differences were observed only with respect to CYP2B6*1/*1 genotypes. Ours is the first report of the CYP2B6 genotype-dependent effect of RIF on long-term EFV autoinduction. Clinical Pharmacology & Therapeutics (2011) 90 3, 406-413. doi:10.1038/clpt.2011.129 | ||
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