Educational attainment is associated with kidney and cardiovascular outcomes in the German CKD (GCKD) cohort
Introduction - Prospective data on impact of educational attainment on prognosis in patients with chronic kidney disease (CKD) are scarce. We investigated the association between educational attainment and all-cause mortality, major adverse cardiovascular (CV) events (MACEs), kidney failure requirin...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
14 February 202
|
| In: |
Kidney international. Reports
Year: 2022, Jahrgang: 7, Heft: 5, Pages: 1004-1015 |
| ISSN: | 2468-0249 |
| DOI: | 10.1016/j.ekir.2022.02.001 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ekir.2022.02.001 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2468024922011378 
|
| Verfasserangaben: | Doris Winitzki, Helena U. Zacharias, Jennifer Nadal, Seema Baid-Agrawal, Elke Schaeffner, Matthias Schmid, Martin Busch, Manuela M. Bergmann, Ulla Schultheiss, Fruzsina Kotsis, Helena Stockmann, Heike Meiselbach, Gunter Wolf, Vera Krane, Claudia Sommerer, Kai-Uwe Eckardt, Markus P. Schneider, Georg Schlieper, Jürgen Floege, Turgay Saritas ; for the German Chronic Kidney Disease (GCKD) Investigators |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1817371134 | ||
| 003 | DE-627 | ||
| 005 | 20250109055444.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220925s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ekir.2022.02.001 |2 doi | |
| 035 | |a (DE-627)1817371134 | ||
| 035 | |a (DE-599)KXP1817371134 | ||
| 035 | |a (OCoLC)1361696179 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Winitzki, Doris |d 1992- |e VerfasserIn |0 (DE-588)1268840289 |0 (DE-627)1817371126 |4 aut | |
| 245 | 1 | 0 | |a Educational attainment is associated with kidney and cardiovascular outcomes in the German CKD (GCKD) cohort |c Doris Winitzki, Helena U. Zacharias, Jennifer Nadal, Seema Baid-Agrawal, Elke Schaeffner, Matthias Schmid, Martin Busch, Manuela M. Bergmann, Ulla Schultheiss, Fruzsina Kotsis, Helena Stockmann, Heike Meiselbach, Gunter Wolf, Vera Krane, Claudia Sommerer, Kai-Uwe Eckardt, Markus P. Schneider, Georg Schlieper, Jürgen Floege, Turgay Saritas ; for the German Chronic Kidney Disease (GCKD) Investigators |
| 264 | 1 | |c 14 February 202 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.09.2022 | ||
| 520 | |a Introduction - Prospective data on impact of educational attainment on prognosis in patients with chronic kidney disease (CKD) are scarce. We investigated the association between educational attainment and all-cause mortality, major adverse cardiovascular (CV) events (MACEs), kidney failure requiring dialysis, and CKD etiology. - Methods - Participants (N = 5095, aged 18-74 years) of the ongoing multicenter German Chronic Kidney Disease (GCKD) cohort, enrolled on the basis of an estimated glomerular filtration rate (eGFR) of 30 to 60 ml/min (stages G3, A1-A3) or overt proteinuria (stages G1-G2, A3), were divided into 3 categories according to their educational attainment and were followed for 6.5 years. - Results - Participants with low educational attainment (vs. high) had a higher risk for mortality (hazard ratio [HR] 1.48, 95% CI: 1.16-1.90), MACE (HR 1.37, 95% CI: 1.02-1.83), and kidney failure (HR 1.54, 95% CI: 1.15-2.05). Mediators between low educational attainment and mortality were smoking, CV disease (CVD) at baseline, low income, higher body mass index, and higher serum levels of CRP, high-density lipoprotein cholesterol, uric acid, NGAL, BAP, NT-proBNP, OPN, H-FABP, and urea. Low educational attainment was positively associated with diabetic nephropathy (odds ratio [OR] 1.65, 95% CI: 1.36-2.0) and CKD subsequent to acute kidney injury (OR 1.56, 95% CI: 1.03-2.35), but negatively associated with IgA nephropathy (OR 0.68, 95% CI: 0.52-0.90). - Conclusion - Low educational attainment is associated with adverse outcomes and CKD etiology. Lifestyle habits and biomarkers mediate associations between low educational attainment and mortality. Recognition of the role of educational attainment and the associated health-relevant risk factors is important to optimize the care of patients with CKD and improve prognosis. | ||
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a CASMIN | |
| 650 | 4 | |a chronic kidney disease | |
| 650 | 4 | |a CKD | |
| 650 | 4 | |a educational attainment | |
| 650 | 4 | |a socioeconomic status | |
| 700 | 1 | |8 1\p |a Zacharias, Helena U. |d 1988- |e VerfasserIn |0 (DE-588)1107779103 |0 (DE-627)863608787 |0 (DE-576)475119452 |4 aut | |
| 700 | 1 | |a Nadal, Jennifer |e VerfasserIn |4 aut | |
| 700 | 1 | |8 2\p |a Baid-Agrawal, Seema |e VerfasserIn |0 (DE-588)1020728094 |0 (DE-627)689002165 |0 (DE-576)361892772 |4 aut | |
| 700 | 1 | |a Schaeffner, Elke |e VerfasserIn |4 aut | |
| 700 | 1 | |8 3\p |a Schmid, Matthias |e VerfasserIn |0 (DE-588)1068404426 |0 (DE-627)820226939 |0 (DE-576)42775707X |4 aut | |
| 700 | 1 | |8 4\p |a Busch, Martin |d 1984- |e VerfasserIn |0 (DE-588)1078131473 |0 (DE-627)838026966 |0 (DE-576)448969610 |4 aut | |
| 700 | 1 | |8 5\p |a Bergmann, Manuela |e VerfasserIn |0 (DE-588)1222049554 |0 (DE-627)1740826833 |4 aut | |
| 700 | 1 | |a Schultheiss, Ulla |e VerfasserIn |4 aut | |
| 700 | 1 | |8 6\p |a Kotsis, Fruzsina |d 1978- |e VerfasserIn |0 (DE-588)134145577 |0 (DE-627)561358451 |0 (DE-576)278317030 |4 aut | |
| 700 | 1 | |8 7\p |a Stockmann, Helena |d 1991- |e VerfasserIn |0 (DE-588)1133218725 |0 (DE-627)888954980 |0 (DE-576)489184650 |4 aut | |
| 700 | 1 | |8 8\p |a Meiselbach, Heike |d 1977- |e VerfasserIn |0 (DE-588)133679039 |0 (DE-627)550686754 |0 (DE-576)300019998 |4 aut | |
| 700 | 1 | |8 9\p |a Wolf, Gunter |d 1961- |e VerfasserIn |0 (DE-588)112832245 |0 (DE-627)51985098X |0 (DE-576)289744024 |4 aut | |
| 700 | 1 | |8 10\p |a Krane, Vera |d 1969- |e VerfasserIn |0 (DE-588)120256347 |0 (DE-627)080556108 |0 (DE-576)29212290X |4 aut | |
| 700 | 1 | |a Sommerer, Claudia |d 1971- |e VerfasserIn |0 (DE-588)121857654 |0 (DE-627)705680002 |0 (DE-576)292921829 |4 aut | |
| 700 | 1 | |8 11\p |a Eckardt, Kai-Uwe |d 1960- |e VerfasserIn |0 (DE-588)110507835 |0 (DE-627)521900182 |0 (DE-576)289675502 |4 aut | |
| 700 | 1 | |a Schneider, Markus P. |e VerfasserIn |4 aut | |
| 700 | 1 | |8 12\p |a Schlieper, Georg Rainer |d 1971- |e VerfasserIn |0 (DE-588)122013514 |0 (DE-627)081682034 |0 (DE-576)293047847 |4 aut | |
| 700 | 1 | |8 13\p |a Flöge, Jürgen |d 1959- |e VerfasserIn |0 (DE-588)110658205 |0 (DE-627)610529153 |0 (DE-576)253430755 |4 aut | |
| 700 | 1 | |a Saritas, Turgay |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Kidney international. Reports |d Amsterdam : Elsevier, 2016 |g 7(2022), 5 vom: Mai, Seite 1004-1015 |h Online-Ressource |w (DE-627)881695580 |w (DE-600)2887223-X |w (DE-576)485146266 |x 2468-0249 |7 nnas |a Educational attainment is associated with kidney and cardiovascular outcomes in the German CKD (GCKD) cohort |
| 773 | 1 | 8 | |g volume:7 |g year:2022 |g number:5 |g month:05 |g pages:1004-1015 |g extent:12 |a Educational attainment is associated with kidney and cardiovascular outcomes in the German CKD (GCKD) cohort |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ekir.2022.02.001 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S2468024922011378 |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 5\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 6\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 7\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 8\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 9\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 10\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 11\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 12\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 13\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20220925 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 121857654 |a Sommerer, Claudia |m 121857654:Sommerer, Claudia |d 50000 |e 50000PS121857654 |k 0/50000/ |p 15 | ||
| 999 | |a KXP-PPN1817371134 |e 4191345362 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Winitzki, Doris","family":"Winitzki","role":"aut","given":"Doris"},{"role":"aut","given":"Helena U.","display":"Zacharias, Helena U.","family":"Zacharias"},{"given":"Jennifer","role":"aut","display":"Nadal, Jennifer","family":"Nadal"},{"given":"Seema","role":"aut","family":"Baid-Agrawal","display":"Baid-Agrawal, Seema"},{"role":"aut","given":"Elke","display":"Schaeffner, Elke","family":"Schaeffner"},{"family":"Schmid","display":"Schmid, Matthias","role":"aut","given":"Matthias"},{"given":"Martin","role":"aut","family":"Busch","display":"Busch, Martin"},{"display":"Bergmann, Manuela","family":"Bergmann","given":"Manuela","role":"aut"},{"family":"Schultheiss","display":"Schultheiss, Ulla","role":"aut","given":"Ulla"},{"display":"Kotsis, Fruzsina","family":"Kotsis","given":"Fruzsina","role":"aut"},{"display":"Stockmann, Helena","family":"Stockmann","role":"aut","given":"Helena"},{"display":"Meiselbach, Heike","family":"Meiselbach","role":"aut","given":"Heike"},{"role":"aut","given":"Gunter","display":"Wolf, Gunter","family":"Wolf"},{"given":"Vera","role":"aut","family":"Krane","display":"Krane, Vera"},{"role":"aut","given":"Claudia","family":"Sommerer","display":"Sommerer, Claudia"},{"display":"Eckardt, Kai-Uwe","family":"Eckardt","given":"Kai-Uwe","role":"aut"},{"family":"Schneider","display":"Schneider, Markus P.","given":"Markus P.","role":"aut"},{"role":"aut","given":"Georg Rainer","display":"Schlieper, Georg Rainer","family":"Schlieper"},{"display":"Flöge, Jürgen","family":"Flöge","given":"Jürgen","role":"aut"},{"role":"aut","given":"Turgay","family":"Saritas","display":"Saritas, Turgay"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Educational attainment is associated with kidney and cardiovascular outcomes in the German CKD (GCKD) cohort","title":"Educational attainment is associated with kidney and cardiovascular outcomes in the German CKD (GCKD) cohort"}],"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"14 February 202"}],"note":["Gesehen am 25.09.2022"],"id":{"doi":["10.1016/j.ekir.2022.02.001"],"eki":["1817371134"]},"recId":"1817371134","relHost":[{"language":["eng"],"titleAlt":[{"title":"KI reports"},{"title":"Kidney international reports"}],"part":{"year":"2022","pages":"1004-1015","text":"7(2022), 5 vom: Mai, Seite 1004-1015","issue":"5","volume":"7","extent":"12"},"origin":[{"publisher":"Elsevier","dateIssuedDisp":"[2016]-","publisherPlace":"Amsterdam"}],"note":["Gesehen am 23.06.20"],"pubHistory":["Volume 1, issue 1 (May 2016)-"],"title":[{"title_sort":"Kidney international","partname":"Reports","title":"Kidney international"}],"disp":"Educational attainment is associated with kidney and cardiovascular outcomes in the German CKD (GCKD) cohortKidney international. Reports","type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"881695580","id":{"eki":["881695580"],"zdb":["2887223-X"],"issn":["2468-0249"]}}],"physDesc":[{"extent":"12 S."}],"name":{"displayForm":["Doris Winitzki, Helena U. Zacharias, Jennifer Nadal, Seema Baid-Agrawal, Elke Schaeffner, Matthias Schmid, Martin Busch, Manuela M. Bergmann, Ulla Schultheiss, Fruzsina Kotsis, Helena Stockmann, Heike Meiselbach, Gunter Wolf, Vera Krane, Claudia Sommerer, Kai-Uwe Eckardt, Markus P. Schneider, Georg Schlieper, Jürgen Floege, Turgay Saritas ; for the German Chronic Kidney Disease (GCKD) Investigators"]}} | ||
| SRT | |a WINITZKIDOEDUCATIONA1420 | ||