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SAFIR-I: design and performance of a high-rate preclinical PET insert for MRI

(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studie...

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Hauptverfasser: Bebié, Pascal (VerfasserIn) , Becker, Robert (VerfasserIn) , Commichau, Volker (VerfasserIn) , Debus, Jan (VerfasserIn) , Dissertori, Günther (VerfasserIn) , Djambazov, Lubomir (VerfasserIn) , Eleftheriou, Afroditi (VerfasserIn) , Fischer, Jannis (VerfasserIn) , Fischer, Peter (VerfasserIn) , Ito, Mikiko (VerfasserIn) , Khateri, Parisa (VerfasserIn) , Lustermann, Werner (VerfasserIn) , Ritzer, Christian (VerfasserIn) , Ritzert, Michael (VerfasserIn) , Röser, Ulf (VerfasserIn) , Tsoumpas, Charalampos (VerfasserIn) , Warnock, Geoffrey (VerfasserIn) , Weber, Bruno (VerfasserIn) , Wyss, Matthias T. (VerfasserIn) , Zagozdzinska-Bochenek, Agnieszka (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 23 October 2021
In: Sensors
Year: 2021, Jahrgang: 21, Heft: 21, Pages: 1-27
ISSN:1424-8220
DOI:10.3390/s21217037
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/s21217037
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1424-8220/21/21/7037
Volltext
Verfasserangaben:Pascal Bebié, Robert Becker, Volker Commichau, Jan Debus, Günther Dissertori, Lubomir Djambazov, Afroditi Eleftheriou, Jannis Fischer, Peter Fischer, Mikiko Ito, Parisa Khateri, Werner Lustermann, Christian Ritzer, Michael Ritzert, Ulf Röser, Charalampos Tsoumpas, Geoffrey Warnock, Bruno Weber, Matthias T. Wyss and Agnieszka Zagozdzinska-Bochenek
Beschreibung
Zusammenfassung:(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500MBq, enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of 54.2mm and an inner diameter of 114mm. It employs Lutetium Yttrium OxyorthoSilicate (LYSO) crystals and Multi Pixel Photon Counter (MPPC) arrays. The Position-Energy-Timing Application Specific Integrated Circuit, version 6, Single Ended (PETA6SE) digitizes the MPPC signals and provides time stamps and energy information. (3) Results: SAFIR-I is MR-compatible. The system’s Coincidence Resolving Time (CRT) and energy resolution are between separate-uncertainty 209.0(3)ps and separate-uncertainty 12.41(02) Full Width at Half Maximum (FWHM) at low activity and separate-uncertainty 326.89(12)ps and separate-uncertainty 20.630(011) FWHM at 550MBq, respectively. The peak sensitivity is ∼1.6. The excellent performance facilitated the successful execution of first in vivo rat studies beyond 300MBq. Based on features visible in the acquired images, we estimate the spatial resolution to be ∼2mm in the center of the Field Of View (FOV). (4) Conclusion: The SAFIR-I PET insert provides excellent performance, permitting simultaneous in vivo small animal PET/MR image acquisitions with time frames of a few seconds in length at activities of up to 500MBq.
Beschreibung:Published: 23 October 2021
Gesehen am 27.09.2022
Beschreibung:Online Resource
ISSN:1424-8220
DOI:10.3390/s21217037

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