Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma
Platelet-derived growth factor receptor (PDGFR) signaling has been implicated in the pathogenesis of glioblastomas and represents a target for the tyrosine kinase inhibitor imatinib. To examine the prognostic or predictive role of PDGFRs in recurrent glioblastomas, expression was examined in tumor s...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
22 February 2011
|
| In: |
International journal of cancer
Year: 2011, Jahrgang: 128, Heft: 8, Pages: 1981-1988 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.25528 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/ijc.25528
|
| Verfasserangaben: | Janna Paulsson, Maja Bradic Lindh, Malin Jarvius, Marjut Puputti, Monica Nistér, Nina N. Nupponen, Werner Paulus, Ola Söderberg, Gregor Dresemann, Andreas von Deimling, Heikki Joensuu, Arne Ostman and Martin Hasselblatt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1817811266 | ||
| 003 | DE-627 | ||
| 005 | 20230710113030.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220929s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ijc.25528 |2 doi | |
| 035 | |a (DE-627)1817811266 | ||
| 035 | |a (DE-599)KXP1817811266 | ||
| 035 | |a (OCoLC)1389782079 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Paulsson, Janna |e VerfasserIn |0 (DE-588)1269143611 |0 (DE-627)1817811746 |4 aut | |
| 245 | 1 | 0 | |a Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma |c Janna Paulsson, Maja Bradic Lindh, Malin Jarvius, Marjut Puputti, Monica Nistér, Nina N. Nupponen, Werner Paulus, Ola Söderberg, Gregor Dresemann, Andreas von Deimling, Heikki Joensuu, Arne Ostman and Martin Hasselblatt |
| 264 | 1 | |c 22 February 2011 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.09.2022 | ||
| 520 | |a Platelet-derived growth factor receptor (PDGFR) signaling has been implicated in the pathogenesis of glioblastomas and represents a target for the tyrosine kinase inhibitor imatinib. To examine the prognostic or predictive role of PDGFRs in recurrent glioblastomas, expression was examined in tumor samples of 101 patients of CSTI571BDE40, a randomized trial comparing hydroxyurea monotherapy and a combination of hydroxyurea and imatinib. Furthermore, PDGFRα phosphorylation was investigated using in situ proximity ligation assay. PDGFRα protein was expressed in 33% of tumors and was associated with male sex, young age, presence of R132H mutated isocitrate dehydrogenase 1 protein and short median survival (142 vs. 187 days, p = 0.028). Tumor PDGFRα phosphorylation was also associated with short survival (p = 0.030). The subset of patients with PDGFRα positive glioblastoma did not have longer survival on treatment with hydroxyurea and imatinib compared with hydroxyurea monotherapy. In conclusion, both PDGFRα protein expression and phosphorylation status had a prognostic role in recurrent glioblastomas but did not define a group that showed benefit from the combination therapy consisting of hydroxyurea and imatinib. | ||
| 650 | 4 | |a Antineoplastic Combined Chemotherapy Protocols | |
| 650 | 4 | |a Benzamides | |
| 650 | 4 | |a Brain Neoplasms | |
| 650 | 4 | |a Drug Resistance, Neoplasm | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Glioblastoma | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Hydroxyurea | |
| 650 | 4 | |a Imatinib Mesylate | |
| 650 | 4 | |a Immunoenzyme Techniques | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Neoplasm Recurrence, Local | |
| 650 | 4 | |a Phosphorylation | |
| 650 | 4 | |a Piperazines | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Pyrimidines | |
| 650 | 4 | |a Receptor, Platelet-Derived Growth Factor alpha | |
| 650 | 4 | |a Survival Rate | |
| 700 | 1 | |a Lindh, Maja Bradic |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jarvius, Malin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Puputti, Marjut |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nistér, Monica |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nupponen, Nina N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Paulus, Werner |e VerfasserIn |4 aut | |
| 700 | 1 | |a Söderberg, Ola |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dresemann, Gregor |e VerfasserIn |4 aut | |
| 700 | 1 | |a Deimling, Andreas von |d 1959- |e VerfasserIn |0 (DE-588)103034115X |0 (DE-627)735093946 |0 (DE-576)378138065 |4 aut | |
| 700 | 1 | |a Joensuu, Heikki |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ostman, Arne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hasselblatt, Martin |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cancer |d Bognor Regis : Wiley-Liss, 1966 |g 128(2011), 8, Seite 1981-1988 |h Online-Ressource |w (DE-627)269532781 |w (DE-600)1474822-8 |w (DE-576)079876129 |x 1097-0215 |7 nnas |a Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma |
| 773 | 1 | 8 | |g volume:128 |g year:2011 |g number:8 |g pages:1981-1988 |g extent:8 |a Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma |
| 856 | 4 | 0 | |u https://doi.org/10.1002/ijc.25528 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220929 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 103034115X |a Deimling, Andreas von |m 103034115X:Deimling, Andreas von |d 910000 |d 912000 |e 910000PD103034115X |e 912000PD103034115X |k 0/910000/ |k 1/910000/912000/ |p 10 | ||
| 999 | |a KXP-PPN1817811266 |e 419342040X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"22 February 2011"}],"name":{"displayForm":["Janna Paulsson, Maja Bradic Lindh, Malin Jarvius, Marjut Puputti, Monica Nistér, Nina N. Nupponen, Werner Paulus, Ola Söderberg, Gregor Dresemann, Andreas von Deimling, Heikki Joensuu, Arne Ostman and Martin Hasselblatt"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1002/ijc.25528"],"eki":["1817811266"]},"recId":"1817811266","person":[{"given":"Janna","display":"Paulsson, Janna","family":"Paulsson","role":"aut"},{"given":"Maja Bradic","role":"aut","family":"Lindh","display":"Lindh, Maja Bradic"},{"given":"Malin","display":"Jarvius, Malin","role":"aut","family":"Jarvius"},{"display":"Puputti, Marjut","role":"aut","family":"Puputti","given":"Marjut"},{"given":"Monica","display":"Nistér, Monica","role":"aut","family":"Nistér"},{"family":"Nupponen","role":"aut","display":"Nupponen, Nina N.","given":"Nina N."},{"display":"Paulus, Werner","role":"aut","family":"Paulus","given":"Werner"},{"given":"Ola","role":"aut","family":"Söderberg","display":"Söderberg, Ola"},{"display":"Dresemann, Gregor","role":"aut","family":"Dresemann","given":"Gregor"},{"given":"Andreas von","display":"Deimling, Andreas von","role":"aut","family":"Deimling"},{"given":"Heikki","family":"Joensuu","role":"aut","display":"Joensuu, Heikki"},{"given":"Arne","family":"Ostman","role":"aut","display":"Ostman, Arne"},{"role":"aut","family":"Hasselblatt","display":"Hasselblatt, Martin","given":"Martin"}],"language":["eng"],"note":["Gesehen am 29.09.2022"],"title":[{"title_sort":"Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma","title":"Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma"}],"physDesc":[{"extent":"8 S."}],"relHost":[{"part":{"extent":"8","pages":"1981-1988","year":"2011","issue":"8","text":"128(2011), 8, Seite 1981-1988","volume":"128"},"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"269532781","titleTranslated":[{"translated":"Journal international du cancer"}],"language":["eng"],"title":[{"title_sort":"International journal of cancer","subtitle":"publication of the International Union against Cancer (UICC) = Journal international du cancer","title":"International journal of cancer"}],"id":{"eki":["269532781"],"zdb":["1474822-8"],"doi":["10.1002/(ISSN)1097-0215"],"issn":["1097-0215"]},"origin":[{"publisher":"Wiley-Liss","dateIssuedDisp":"1966-","publisherPlace":"Bognor Regis","dateIssuedKey":"1966"}],"corporate":[{"display":"International Union against Cancer","role":"isb"}],"disp":"Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastomaInternational journal of cancer","note":["Gesehen am 28.02.08","Darin: Predictive oncology"],"pubHistory":["1.1966 -"],"titleAlt":[{"title":"Predictive oncology"}]}]} | ||
| SRT | |a PAULSSONJAPROGNOSTIC2220 | ||