From catalysts to bioactive organometallics: Do grubbs catalysts trigger biological effects?
Grubbs up! Grubbs-type catalysts have potential as inhibitors of tumor-relevant enzymes, exhibit antiproliferative effects in cultured tumor cells, and influence cell metabolism. While the potencies of these catalysts are poor to moderate from a drug development prospective, their biological activit...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
07 September 2011
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| In: |
ChemMedChem
Year: 2011, Jahrgang: 6, Heft: 12, Pages: 2142-2145 |
| ISSN: | 1860-7187 |
| DOI: | 10.1002/cmdc.201100308 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/cmdc.201100308 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201100308 |
| Verfasserangaben: | Luciano Oehninger, Hamed Alborzinia, Stephanie Ludewig, Knut Baumann, Stefan Wölfl, and Ingo Ott |
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| 520 | |a Grubbs up! Grubbs-type catalysts have potential as inhibitors of tumor-relevant enzymes, exhibit antiproliferative effects in cultured tumor cells, and influence cell metabolism. While the potencies of these catalysts are poor to moderate from a drug development prospective, their biological activity suggests that incorporating aspects of their structures could be beneficial for drug design. | ||
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