Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study
Cerebral amyloid angiopathy is manifested as accumulation of amyloid β (Aβ) peptide in the wall of meningeal and cerebral arteries, arterioles and capillaries and is frequently found postmortem in sporadic Alzheimer’s disease (sAD) patients. It is difficult to assess when and how cerebral amyloid an...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 April 2011
|
| In: |
Journal of neural transmission
Year: 2011, Jahrgang: 118, Heft: 5, Pages: 765-772 |
| ISSN: | 1435-1463 |
| DOI: | 10.1007/s00702-011-0651-4 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00702-011-0651-4
|
| Verfasserangaben: | Melita Salkovic-Petrisic, Jelena Osmanovic-Barilar, Martina K. Brückner, Siegfried Hoyer, Thomas Arendt, Peter Riederer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1817966278 | ||
| 003 | DE-627 | ||
| 005 | 20240417193715.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221004s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00702-011-0651-4 |2 doi | |
| 035 | |a (DE-627)1817966278 | ||
| 035 | |a (DE-599)KXP1817966278 | ||
| 035 | |a (OCoLC)1389781381 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Salkovic-Petrisic, Melita |e VerfasserIn |0 (DE-588)1022645420 |0 (DE-627)717019977 |0 (DE-576)36573067X |4 aut | |
| 245 | 1 | 0 | |a Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease |b a long-term follow up study |c Melita Salkovic-Petrisic, Jelena Osmanovic-Barilar, Martina K. Brückner, Siegfried Hoyer, Thomas Arendt, Peter Riederer |
| 264 | 1 | |c 30 April 2011 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.10.2022 | ||
| 520 | |a Cerebral amyloid angiopathy is manifested as accumulation of amyloid β (Aβ) peptide in the wall of meningeal and cerebral arteries, arterioles and capillaries and is frequently found postmortem in sporadic Alzheimer’s disease (sAD) patients. It is difficult to assess when and how cerebral amyloid angiopathy develops and progresses in humans in vivo, which is why animal AD models are used. Streptozotocin-intracerebroventricularly (STZ-icv) treated rats have been recently proposed as the model of sAD which develops insulin resistant brain state preceding Aβ pathology development. Vascular Aβ deposits in the brain of STZ-icv-treated rats (3 months old at the time of icv treatment) were visualized by Thioflavine-S staining, Congo red staining and Aβ immunohistochemistry. Thioflavine-S and Congo red staining revealed diffuse congophilic deposits in the wall of meningeal and cortical blood vessels both 6 and 9 months after the STZ-icv treatment. Preliminary Aβ1-42 and Aβ1-16 immunohistochemistry experiments showed positive staining in blood vessels 3 and 9 months after the STZ-icv treatment, respectively. Results suggest that cerebral amyloid angiopathy observed 6 and 9 months after the STZ-icv treatment seems to be a continuation and progression of the amyloid pathology observed already 3 months following the STZ-icv treatment in this non-transgenic sAD animal model. | ||
| 650 | 4 | |a Amyloid β | |
| 650 | 4 | |a Cerebral amyloid angiopathy | |
| 650 | 4 | |a Intracerebroventricular | |
| 650 | 4 | |a Streptozotocin | |
| 700 | 1 | |a Osmanovic-Barilar, Jelena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brückner, Martina K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoyer, Siegfried |d 1933-2014 |e VerfasserIn |0 (DE-588)133236773 |0 (DE-627)539307343 |0 (DE-576)299715469 |4 aut | |
| 700 | 1 | |a Arendt, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Riederer, Peter |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neural transmission |d Wien [u.a.] : Springer, 1950 |g 118(2011), 5, Seite 765-772 |h Online-Ressource |w (DE-627)300185901 |w (DE-600)1481655-6 |w (DE-576)09450542X |x 1435-1463 |7 nnas |a Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease a long-term follow up study |
| 773 | 1 | 8 | |g volume:118 |g year:2011 |g number:5 |g pages:765-772 |g extent:8 |a Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease a long-term follow up study |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |t Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease |d 2011 |w (DE-627)1632693453 |w (DE-576)365730505 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00702-011-0651-4 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221004 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 133236773 |a Hoyer, Siegfried |m 133236773:Hoyer, Siegfried |d 910000 |d 912000 |e 910000PH133236773 |e 912000PH133236773 |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 999 | |a KXP-PPN1817966278 |e 4194202864 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease","subtitle":"a long-term follow up study","title_sort":"Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease"}],"note":["Gesehen am 04.10.2022"],"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"30 April 2011"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"person":[{"role":"aut","given":"Melita","family":"Salkovic-Petrisic","display":"Salkovic-Petrisic, Melita"},{"display":"Osmanovic-Barilar, Jelena","family":"Osmanovic-Barilar","role":"aut","given":"Jelena"},{"role":"aut","given":"Martina K.","family":"Brückner","display":"Brückner, Martina K."},{"display":"Hoyer, Siegfried","family":"Hoyer","role":"aut","given":"Siegfried"},{"role":"aut","given":"Thomas","display":"Arendt, Thomas","family":"Arendt"},{"role":"aut","given":"Peter","display":"Riederer, Peter","family":"Riederer"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.1950 -"],"recId":"300185901","id":{"zdb":["1481655-6"],"issn":["1435-1463"],"eki":["300185901"]},"corporate":[{"role":"isb","display":"European Society for Clinical Neuropharmacology"}],"disp":"Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease a long-term follow up studyJournal of neural transmission","note":["Gesehen am 18.10.05"],"origin":[{"publisherPlace":"Wien [u.a.]","dateIssuedDisp":"1950-","publisher":"Springer","dateIssuedKey":"1950"}],"title":[{"title":"Journal of neural transmission","title_sort":"Journal of neural transmission"}],"titleAlt":[{"title":"Acta neurovegetativa"},{"title":"Journal of neuro-visceral relations"},{"title":"Journal of neural transmission / General section"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"8","volume":"118","year":"2011","text":"118(2011), 5, Seite 765-772","pages":"765-772","issue":"5"},"language":["eng"]}],"id":{"doi":["10.1007/s00702-011-0651-4"],"eki":["1817966278"]},"name":{"displayForm":["Melita Salkovic-Petrisic, Jelena Osmanovic-Barilar, Martina K. Brückner, Siegfried Hoyer, Thomas Arendt, Peter Riederer"]},"physDesc":[{"extent":"8 S."}],"recId":"1817966278"} | ||
| SRT | |a SALKOVICPECEREBRALAM3020 | ||