2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites
Previously we described a series of 5-acylaminobenzophenones with considerable antimalarial activity. Unfortunately, most compounds also displayed high cytotoxicity resulting in low selectivity towards malaria parasites. Through the replacement of the 5-acylamino moiety by simple chlorine and furthe...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[April 2011]
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| In: |
European journal of medicinal chemistry
Year: 2011, Jahrgang: 46, Heft: 4, Pages: 1331-1342 |
| ISSN: | 1768-3254 |
| DOI: | 10.1016/j.ejmech.2011.01.056 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejmech.2011.01.056 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S022352341100078X 
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| Verfasserangaben: | Swetlana Heinrich, Mirko Altenkämper, Benjamin Bechem, Johann Perruchon, Regina Ortmann, Hans-Martin Dahse, Yulin Wang, Michael Lanzer, Martin Schlitzer |
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| 245 | 1 | 0 | |a 2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites |c Swetlana Heinrich, Mirko Altenkämper, Benjamin Bechem, Johann Perruchon, Regina Ortmann, Hans-Martin Dahse, Yulin Wang, Michael Lanzer, Martin Schlitzer |
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| 520 | |a Previously we described a series of 5-acylaminobenzophenones with considerable antimalarial activity. Unfortunately, most compounds also displayed high cytotoxicity resulting in low selectivity towards malaria parasites. Through the replacement of the 5-acylamino moiety by simple chlorine and further modifications of the 2-acylamino residue we could obtain inhibitors with improved selectivity towards malaria parasites combined with an acceptable reduction of antimalarial activity. | ||
| 650 | 4 | |a Antimalarial agents | |
| 650 | 4 | |a Benzophenone derivatives | |
| 650 | 4 | |a Enhanced selectivity | |
| 650 | 4 | |a Plasmodium falciparum | |
| 650 | 4 | |a QSAR | |
| 700 | 1 | |a Altenkämper, Mirko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bechem, Benjamin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Perruchon, Johann |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ortmann, Regina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dahse, Hans-Martin |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Schlitzer, Martin |e VerfasserIn |4 aut | |
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