Shortcomings of administrative data to derive preventive strategies for inhospital drug-induced acute kidney failure: insights from patient record analysis
Structured analyses of hospital administrative data may detect potentially preventable adverse drug events (ADE) and therefore are considered promising sources to prevent future harm and estimate cost savings. Whether results of these analyses indeed correspond to ADE that may be preventable in clin...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 July 2022
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| In: |
Journal of Clinical Medicine
Year: 2022, Volume: 11, Issue: 15, Pages: 1-10 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm11154285 |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.3390/jcm11154285 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/11/15/4285 
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| Author Notes: | Stefanie Amelung, David Czock, Markus Thalheimer, Torsten Hoppe-Tichy, Walter E. Haefeli and Hanna M. Seidling |
| Summary: | Structured analyses of hospital administrative data may detect potentially preventable adverse drug events (ADE) and therefore are considered promising sources to prevent future harm and estimate cost savings. Whether results of these analyses indeed correspond to ADE that may be preventable in clinical routines needs to be verified. We exemplarily screened all adult inpatients admitted to a German University Hospital (n = 54,032) for International Classification of Diseases-10th revision (ICD-10) diagnoses coding for drug-induced kidney injury (AKI). In a retrospective chart review, we checked the coded adverse events (AE) for inhospital occurrence, causality to drug exposure, and preventability in all identified cases and calculated positive predictive values (ppv). We identified 69 inpatient cases of whom 41 cases (59.4%) experienced the AE in the hospital (ppv-range 0.43–0.80). Causality assessment revealed a rather likely causal relationship between AE and drug exposure in 11 cases (15.9, 11/69, ppv-range 0.17–0.22) whereby preventability measures could be postulated for seven cases (10.1%, 7/69). Focusing on drug-induced AKI, this study exemplarily underlines that ICD-10-code-based ADE prevention efforts are quite limited due to the small identification rate and its high proportion of primarily outpatient events. Furthermore, causality assessment revealed that cases are often too complex to benefit from generic prevention strategies. Thus, ICD-10-code-based calculations might overestimate patient harm and economic losses. |
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| Item Description: | Gesehen am 06.10.2022 |
| Physical Description: | Online Resource |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm11154285 |