Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemia
GDF-15 is a novel distant member of the TGF-β superfamily and is widely distributed in the brain and peripheral nervous system. We have previously reported that GDF-15 is a potent neurotrophic factor for lesioned dopaminergic neurons in the substantia nigra, and that GDF-15-deficient mice show progr...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
|
| In: |
Cell & tissue research
Year: 2011, Volume: 343, Issue: 2, Pages: 399-409 |
| ISSN: | 1432-0878 |
| DOI: | 10.1007/s00441-010-1090-5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00441-010-1090-5
|
| Author Notes: | Katharina Schindowski, Oliver von Bohlen und Halbach, Jens Strelau, Dirk A. Ridder, Oliver Herrmann, Andreas Schober, Markus Schwaninger, Klaus Unsicker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 181858249X | ||
| 003 | DE-627 | ||
| 005 | 20251106094408.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221011s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00441-010-1090-5 |2 doi | |
| 035 | |a (DE-627)181858249X | ||
| 035 | |a (DE-599)KXP181858249X | ||
| 035 | |a (OCoLC)1389769148 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schindowski, Katharina |d 1972- |e VerfasserIn |0 (DE-588)123858844 |0 (DE-627)085485691 |0 (DE-576)29391303X |4 aut | |
| 245 | 1 | 0 | |a Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemia |c Katharina Schindowski, Oliver von Bohlen und Halbach, Jens Strelau, Dirk A. Ridder, Oliver Herrmann, Andreas Schober, Markus Schwaninger, Klaus Unsicker |
| 246 | 3 | 0 | |a fifteen beta |
| 264 | 1 | |c 2011 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 3 December 2010 | ||
| 500 | |a Gesehen am 11.10.2022 | ||
| 520 | |a GDF-15 is a novel distant member of the TGF-β superfamily and is widely distributed in the brain and peripheral nervous system. We have previously reported that GDF-15 is a potent neurotrophic factor for lesioned dopaminergic neurons in the substantia nigra, and that GDF-15-deficient mice show progressive postnatal losses of motor and sensory neurons. We have now investigated the regulation of GDF-15 mRNA and immunoreactivity in the murine hippocampal formation and selected cortical areas following an ischemic lesion by occlusion of the middle cerebral artery (MCAO). MCAO prominently upregulates GDF-15 mRNA in the hippocampus and parietal cortex at 3 h and 24 h after lesion. GDF-15 immunoreactivity, which is hardly detectable in the unlesioned brain, is drastically upregulated in neurons identified by double-staining with NeuN. NeuN staining reveals that most, if not all, neurons in the granular layer of the dentate gyrus and pyramidal layers of the cornu ammonis become GDF-15-immunoreactive. Moderate induction of GDF-15 immunoreactivity has been observed in a small number of microglial cells identified by labeling with tomato lectin, whereas astroglial cells remain GDF-15-negative after MCAO. Comparative analysis of the size of the infarcted area after MCAO in GDF-15 wild-type and knockout mice has failed to reveal significant differences. Together, our data substantiate the notion that GDF-15 is prominently upregulated in the lesioned brain and might be involved in orchestrating post-lesional responses other than the trophic support of neurons. | ||
| 650 | 4 | |a Cortex | |
| 650 | 4 | |a Expression | |
| 650 | 4 | |a GDF-15 knockout | |
| 650 | 4 | |a Growth/differentiation factor-15 | |
| 650 | 4 | |a Hippocampus | |
| 650 | 4 | |a Ischemia | |
| 650 | 4 | |a Mouse (adult, male, C57BL/6) | |
| 650 | 4 | |a Occlusion of the middle cerebral artery | |
| 700 | 1 | |a von Bohlen und Halbach, Oliver |e VerfasserIn |4 aut | |
| 700 | 1 | |a Strelau, Jens |e VerfasserIn |0 (DE-588)1055073841 |0 (DE-627)792630645 |0 (DE-576)411144456 |4 aut | |
| 700 | 1 | |a Ridder, Dirk |d 1979- |e VerfasserIn |0 (DE-588)140792775 |0 (DE-627)621611506 |0 (DE-576)320797058 |4 aut | |
| 700 | 1 | |a Herrmann, Oliver |d 1973- |e VerfasserIn |0 (DE-588)131492799 |0 (DE-627)509815596 |0 (DE-576)252794648 |4 aut | |
| 700 | 1 | |a Schober, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwaninger, Markus |e VerfasserIn |0 (DE-588)1028374909 |0 (DE-627)730623939 |0 (DE-576)375910174 |4 aut | |
| 700 | 1 | |a Unsicker, Klaus |d 1942- |e VerfasserIn |0 (DE-588)106365614 |0 (DE-627)503360635 |0 (DE-576)289555515 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell & tissue research |d Berlin : Springer, 1974 |g 343(2011), 2, Seite 399-409 |h Online-Ressource |w (DE-627)253390516 |w (DE-600)1458496-7 |w (DE-576)07228353X |x 1432-0878 |7 nnas |a Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemia |
| 773 | 1 | 8 | |g volume:343 |g year:2011 |g number:2 |g pages:399-409 |g extent:11 |a Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemia |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00441-010-1090-5 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221011 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 106365614 |a Unsicker, Klaus |m 106365614:Unsicker, Klaus |d 50000 |e 50000PU106365614 |k 0/50000/ |p 8 |y j | ||
| 998 | |g 1028374909 |a Schwaninger, Markus |m 1028374909:Schwaninger, Markus |d 50000 |d 140000 |e 50000PS1028374909 |e 140000PS1028374909 |k 0/50000/ |k 0/140000/ |p 7 | ||
| 998 | |g 131492799 |a Herrmann, Oliver |m 131492799:Herrmann, Oliver |d 50000 |e 50000PH131492799 |k 0/50000/ |p 5 | ||
| 998 | |g 1055073841 |a Strelau, Jens |m 1055073841:Strelau, Jens |d 50000 |d 53100 |e 50000PS1055073841 |e 53100PS1055073841 |k 0/50000/ |k 1/50000/53100/ |p 3 | ||
| 999 | |a KXP-PPN181858249X |e 4196069940 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","given":"Katharina","display":"Schindowski, Katharina","family":"Schindowski"},{"given":"Oliver","role":"aut","display":"von Bohlen und Halbach, Oliver","family":"von Bohlen und Halbach"},{"given":"Jens","role":"aut","family":"Strelau","display":"Strelau, Jens"},{"display":"Ridder, Dirk","family":"Ridder","role":"aut","given":"Dirk"},{"role":"aut","given":"Oliver","family":"Herrmann","display":"Herrmann, Oliver"},{"family":"Schober","display":"Schober, Andreas","given":"Andreas","role":"aut"},{"display":"Schwaninger, Markus","family":"Schwaninger","role":"aut","given":"Markus"},{"family":"Unsicker","display":"Unsicker, Klaus","role":"aut","given":"Klaus"}],"language":["eng"],"note":["Published online: 3 December 2010","Gesehen am 11.10.2022"],"origin":[{"dateIssuedDisp":"2011","dateIssuedKey":"2011"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemia","title":"Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemia"}],"recId":"181858249X","name":{"displayForm":["Katharina Schindowski, Oliver von Bohlen und Halbach, Jens Strelau, Dirk A. Ridder, Oliver Herrmann, Andreas Schober, Markus Schwaninger, Klaus Unsicker"]},"physDesc":[{"extent":"11 S."}],"relHost":[{"disp":"Regulation of GDF-15, a distant TGF-β superfamily member, in a mouse model of cerebral ischemiaCell & tissue research","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 24.04.25"],"origin":[{"publisherPlace":"Berlin ; Heidelberg","dateIssuedDisp":"1974-","publisher":"Springer","dateIssuedKey":"1974"}],"titleAlt":[{"title":"Cell and tissue research"}],"title":[{"title":"Cell & tissue research","title_sort":"Cell & tissue research"}],"part":{"issue":"2","extent":"11","volume":"343","year":"2011","pages":"399-409","text":"343(2011), 2, Seite 399-409"},"pubHistory":["Volume 148, issue 1 (March 1974)-"],"recId":"253390516","physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1458496-7"],"issn":["1432-0878"],"eki":["253390516"]}}],"id":{"eki":["181858249X"],"doi":["10.1007/s00441-010-1090-5"]}} | ||
| SRT | |a SCHINDOWSKREGULATION2011 | ||