Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors

Tissue homeostasis and remodeling are processes that involve high turnover of biological macromolecules. Many of the waste molecules that are by-products or degradation intermediates of biological macromolecule turnover enter the circulation and are subsequently cleared by liver sinusoidal endotheli...

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Main Authors: Schledzewski, Kai (Author) , Géraud, Cyrill (Author) , Arnold, Bernd (Author) , Wang, Shijun (Author) , Gröne, Hermann-Josef (Author) , Kempf, Tibor (Author) , Wollert, Kai Christoph (Author) , Straub, Beate Katharina (Author) , Schirmacher, Peter (Author) , Demory, Alexandra (Author) , Schönhaber, Hiltrud (Author) , Gratchev, Alexei (Author) , Dietz, Lisa (Author) , Thierse, Hermann-Josef (Author) , Kzhyshkowska, Julia (Author) , Goerdt, Sergij (Author)
Format: Article (Journal)
Language:English
Published: January 10, 2011
In: The journal of clinical investigation
Year: 2011, Volume: 121, Issue: 2, Pages: 703-714
ISSN:1558-8238
DOI:10.1172/JCI44740
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1172/JCI44740
Verlag, lizenzpflichtig, Volltext: https://www.jci.org/articles/view/44740
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Author Notes:Kai Schledzewski, Cyrill Géraud, Bernd Arnold, Shijun Wang, Hermann-Josef Gröne, Tibor Kempf, Kai C. Wollert, Beate K. Straub, Peter Schirmacher, Alexandra Demory, Hiltrud Schönhaber, Alexei Gratchev, Lisa Dietz, Hermann-Josef Thierse, Julia Kzhyshkowska, and Sergij Goerdt
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