Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells
Airway epithelial cells regulate immune reactivity of local dendritic cells (DCs), thus contributing to microenvironment homeostasis. In this study, we set out to identify factors that mediate this regulatory interaction. We show that tracheal epithelial cells secrete soluble factors that downregula...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2, 2011
|
| In: |
The journal of immunology
Year: 2011, Jahrgang: 186, Heft: 4, Pages: 2095-2105 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.1002414 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.1002414 Verlag, lizenzpflichtig, Volltext: https://www.jimmunol.org/content/186/4/2095 
|
| Verfasserangaben: | Lotte M. Schmidt, Maria G. Belvisi, Konrad A. Bode, Judith Bauer, Claudia Schmidt, Maria-Theresia Suchy, Dimitrios Tsikas, Jutta Scheuerer, Felix Lasitschka, Herman-Josef Gröne, and Alexander H. Dalpke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1818860457 | ||
| 003 | DE-627 | ||
| 005 | 20230710111134.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221013s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4049/jimmunol.1002414 |2 doi | |
| 035 | |a (DE-627)1818860457 | ||
| 035 | |a (DE-599)KXP1818860457 | ||
| 035 | |a (OCoLC)1389768915 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmidt, Lotte M. |e VerfasserIn |0 (DE-588)1019234989 |0 (DE-627)684599082 |0 (DE-576)357277694 |4 aut | |
| 245 | 1 | 0 | |a Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells |c Lotte M. Schmidt, Maria G. Belvisi, Konrad A. Bode, Judith Bauer, Claudia Schmidt, Maria-Theresia Suchy, Dimitrios Tsikas, Jutta Scheuerer, Felix Lasitschka, Herman-Josef Gröne, and Alexander H. Dalpke |
| 246 | 3 | 0 | |a two |
| 246 | 3 | 3 | |a Bronchial epithelial cell-derived prostaglandin E 2 dampens the reactivity of dendritic cells |
| 264 | 1 | |c February 2, 2011 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 13.10.2022 | ||
| 500 | |a Im Titel ist die Zahl 2 tiefgestellt | ||
| 520 | |a Airway epithelial cells regulate immune reactivity of local dendritic cells (DCs), thus contributing to microenvironment homeostasis. In this study, we set out to identify factors that mediate this regulatory interaction. We show that tracheal epithelial cells secrete soluble factors that downregulate TNF-α and IL-12p40 secretion by bone marrow-derived DCs but upregulate IL-10 and arginase-1. Size exclusion chromatography identified small secreted molecules having high modulatory activity on DCs. We observed that airway tracheal epithelial cells constitutively release the lipid mediator PGE2. Blocking the synthesis of PGs within airway epithelial cells relieved DCs from inhibition. Cyclooxygenase-2 was found to be expressed in primary tracheal epithelial cell cultures in vitro and in vivo as shown by microdissection of epithelial cells followed by real-time PCR. Paralleling these findings we observed that DCs treated with an antagonist for E-prostanoid 4 receptor as well as DCs lacking E-prostanoid 4 receptor showed reduced inhibition by airway epithelial cells with respect to secretion of proinflammatory cytokines measured by ELISA. Furthermore, PGE2 mimicked the effects of epithelial cells on DCs. The results indicate that airway epithelial cell-derived PGE2 contributes to the modulation of DCs under homeostatic conditions. | ||
| 700 | 1 | |a Belvisi, Maria G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bode, Konrad A. |d 1969- |e VerfasserIn |0 (DE-588)128891270 |0 (DE-627)384629334 |0 (DE-576)297385836 |4 aut | |
| 700 | 1 | |a Bauer, Judith |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmidt, Claudia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Suchy, Maria-Theresia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tsikas, Dimitrios |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scheuerer, Jutta |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lasitschka, Felix |d 1979- |e VerfasserIn |0 (DE-588)140496343 |0 (DE-627)618903542 |0 (DE-576)318526077 |4 aut | |
| 700 | 1 | |a Gröne, Hermann-Josef |d 1950- |e VerfasserIn |0 (DE-588)1054822697 |0 (DE-627)792339541 |0 (DE-576)170213773 |4 aut | |
| 700 | 1 | |a Dalpke, Alexander |d 1971- |e VerfasserIn |0 (DE-588)123821878 |0 (DE-627)706438523 |0 (DE-576)293894272 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of immunology |d Rockville, Md. : American Association of Immunologists, 1916 |g 186(2011), 4, Seite 2095-2105 |h Online-Ressource |w (DE-627)269535217 |w (DE-600)1475085-5 |w (DE-576)079963838 |x 1550-6606 |7 nnas |a Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells |
| 773 | 1 | 8 | |g volume:186 |g year:2011 |g number:4 |g pages:2095-2105 |g extent:11 |a Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |t Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells |d 2011 |w (DE-627)1632901471 |w (DE-576)36608092X |
| 856 | 4 | 0 | |u https://doi.org/10.4049/jimmunol.1002414 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.jimmunol.org/content/186/4/2095 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221013 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 123821878 |a Dalpke, Alexander |m 123821878:Dalpke, Alexander |d 50000 |e 50000PD123821878 |k 0/50000/ |p 11 |y j | ||
| 998 | |g 1054822697 |a Gröne, Hermann-Josef |m 1054822697:Gröne, Hermann-Josef |d 50000 |e 50000PG1054822697 |k 0/50000/ |p 10 | ||
| 998 | |g 140496343 |a Lasitschka, Felix |m 140496343:Lasitschka, Felix |d 910000 |d 912000 |e 910000PL140496343 |e 912000PL140496343 |k 0/910000/ |k 1/910000/912000/ |p 9 | ||
| 998 | |g 128891270 |a Bode, Konrad A. |m 128891270:Bode, Konrad A. |d 50000 |e 50000PB128891270 |k 0/50000/ |p 3 | ||
| 998 | |g 1019234989 |a Schmidt, Lotte M. |m 1019234989:Schmidt, Lotte M. |d 910000 |d 911700 |e 910000PS1019234989 |e 911700PS1019234989 |k 0/910000/ |k 1/910000/911700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1818860457 |e 4196654800 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells","title_sort":"Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells"}],"recId":"1818860457","type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"name":{"displayForm":["Lotte M. Schmidt, Maria G. Belvisi, Konrad A. Bode, Judith Bauer, Claudia Schmidt, Maria-Theresia Suchy, Dimitrios Tsikas, Jutta Scheuerer, Felix Lasitschka, Herman-Josef Gröne, and Alexander H. Dalpke"]},"note":["Gesehen am 13.10.2022","Im Titel ist die Zahl 2 tiefgestellt"],"person":[{"roleDisplay":"VerfasserIn","family":"Schmidt","role":"aut","display":"Schmidt, Lotte M.","given":"Lotte M."},{"family":"Belvisi","roleDisplay":"VerfasserIn","display":"Belvisi, Maria G.","role":"aut","given":"Maria G."},{"given":"Konrad A.","display":"Bode, Konrad A.","role":"aut","family":"Bode","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Bauer, Judith","given":"Judith","roleDisplay":"VerfasserIn","family":"Bauer"},{"roleDisplay":"VerfasserIn","family":"Schmidt","display":"Schmidt, Claudia","role":"aut","given":"Claudia"},{"role":"aut","display":"Suchy, Maria-Theresia","given":"Maria-Theresia","family":"Suchy","roleDisplay":"VerfasserIn"},{"given":"Dimitrios","display":"Tsikas, Dimitrios","role":"aut","roleDisplay":"VerfasserIn","family":"Tsikas"},{"roleDisplay":"VerfasserIn","family":"Scheuerer","display":"Scheuerer, Jutta","role":"aut","given":"Jutta"},{"display":"Lasitschka, Felix","role":"aut","given":"Felix","roleDisplay":"VerfasserIn","family":"Lasitschka"},{"family":"Gröne","roleDisplay":"VerfasserIn","role":"aut","display":"Gröne, Hermann-Josef","given":"Hermann-Josef"},{"given":"Alexander","role":"aut","display":"Dalpke, Alexander","family":"Dalpke","roleDisplay":"VerfasserIn"}],"physDesc":[{"extent":"11 S."}],"titleAlt":[{"title":"Bronchial epithelial cell-derived prostaglandin E 2 dampens the reactivity of dendritic cells"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 18.08.2025"],"origin":[{"publisherPlace":"Oxford ; Bethesda, Md. ; Rockville, Md.","dateIssuedDisp":"2025-","publisher":"Oxford University Press ; Soc. ; American Association of Immunologists","dateIssuedKey":"2025"}],"id":{"zdb":["1475085-5"],"issn":["1550-6606"],"eki":["269535217"]},"recId":"269535217","title":[{"title":"The journal of immunology","title_sort":"journal of immunology"}],"disp":"Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cellsThe journal of immunology","name":{"displayForm":["American Association of Immunologists"]},"part":{"year":"2011","text":"186(2011), 4, Seite 2095-2105","pages":"2095-2105","extent":"11","volume":"186","issue":"4"},"pubHistory":["1.1916 -"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"American Association of Immunologists"}]}],"id":{"doi":["10.4049/jimmunol.1002414"],"eki":["1818860457"]},"origin":[{"dateIssuedDisp":"February 2, 2011","dateIssuedKey":"2011"}]} | ||
| SRT | |a SCHMIDTLOTBRONCHIALE2201 | ||