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Relationship between vitamin D status and antibody response to COVID-19 mRNA vaccination in healthy adults

The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-c...

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Main Authors: Chillon, Thilo Samson (Author) , Demircan, Kamil (Author) , Heller, Raban (Author) , Hirschbil-Bremer, Ines Maria (Author) , Diegmann, Joachim (Author) , Bachmann, Manuel (Author) , Moghaddam-Alvandi, Arash (Author) , Schomburg, Lutz (Author)
Format: Article (Journal)
Language:English
Published: 18 November 2021
In: Biomedicines
Year: 2021, Volume: 9, Issue: 11, Pages: 1-18
ISSN:2227-9059
DOI:10.3390/biomedicines9111714
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/biomedicines9111714
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2227-9059/9/11/1714
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Author Notes:Thilo Samson Chillon, Kamil Demircan, Raban Arved Heller, Ines Maria Hirschbil-Bremer, Joachim Diegmann, Manuel Bachmann, Arash Moghaddam and Lutz Schomburg
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Summary:The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-cholecalciferol [25(OH)D] concentrations in a cohort of healthy German adults from the time of vaccination over 24 weeks. Contrary to our expectations, no significant differences were found in the dynamic increase or decrease of SARS-CoV-2 IgG as a function of the 25(OH)D status. Furthermore, the response to the first or second vaccination, the maximum SARS-CoV-2 IgG concentrations achieved, and the decline in SARS-CoV-2 IgG concentrations over time were not related to 25(OH)D status. We conclude that the vaccination response, measured as SARS-CoV-2 IgG concentration, does not depend on 25(OH)D status in healthy adults with moderate vitamin D status.
Item Description:Gesehen am 18.10.2022
Physical Description:Online Resource
ISSN:2227-9059
DOI:10.3390/biomedicines9111714

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