Protocol of the TREASURE study: Thoracic RadiothErapy with Atezolizumab in Small cell lUng canceR Extensive disease$da randomized, open-label, multicenter phase II trial
Recently, the combination of the programmed death-ligand 1 (PD-L1) inhibitor atezolizumab with first-line chemotherapy has demonstrated to improve outcome for patients with advanced small cell lung cancer (SCLC), leading to approval of this regimen. At the same time, accumulating (pre-)clinical data...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 September 2022
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| In: |
BMC cancer
Year: 2022, Volume: 22, Pages: 1-9 |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-022-10074-9 |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/s12885-022-10074-9 Verlag, kostenfrei, Volltext: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-10074-9 
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| Author Notes: | Farastuk Bozorgmehr, Petros Christopoulos, Inn Chung, Jelena Cvetkovic, Manuel Feißt, Johannes Krisam, Marc A. Schneider, Claus Peter Heußel, Michael Kreuter, Daniel W. Müller, Michael Thomas and Stefan Rieken |
MARC
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| 520 | |a Recently, the combination of the programmed death-ligand 1 (PD-L1) inhibitor atezolizumab with first-line chemotherapy has demonstrated to improve outcome for patients with advanced small cell lung cancer (SCLC), leading to approval of this regimen. At the same time, accumulating (pre-)clinical data suggest synergisms of radiotherapy and immunotherapy via the radiation-mediated induction of anti-tumor immunogenicity. Combining the recent findings, the TREASURE trial aims at further enhancing response to upfront chemo-immunotherapy by the addition of thoracic radiotherapy (TRT). | ||
| 650 | 4 | |a Anti-PD-L1 monoclonal antibody | |
| 650 | 4 | |a Atezolizumab | |
| 650 | 4 | |a Extensive disease small cell lung cancer | |
| 650 | 4 | |a First-line therapy | |
| 650 | 4 | |a Radioimmuntherapy | |
| 650 | 4 | |a SCLC | |
| 650 | 4 | |a Thoracic radiotherapy | |
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