DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy
DNA repair plays an important role in chemoresistance to platinum-based therapy, and therefore polymorphisms in the genes may modulate therapeutic response. We assessed 12 polymorphisms in 7 DNA repair genes and 2 polymorphisms in the MTHFR gene for association with disease response and prognosis.
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 February 2011
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| In: |
Annals of surgical oncology
Year: 2011, Jahrgang: 18, Heft: 9, Pages: 2688-2698 |
| ISSN: | 1534-4681 |
| DOI: | 10.1245/s10434-011-1601-y |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1245/s10434-011-1601-y
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| Verfasserangaben: | Katja Ott, MD, P. Sivaramakrishna Rachakonda, PhD, Benjamin Panzram, PhD, Gisela Keller, MD, Florian Lordick, MD, Karen Becker, MD, Rupert Langer, MD, Markus Buechler, MD, Kari Hemminki, MD, and Rajiv Kumar, PhD |
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