Molecular analysis of Annexin expression in cancer
Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin core domain, present in all members of the Annexin family, becomes exposed on the apoptotic cell-surface and triggers tolerogenic signalling in phagocytes via the D...
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| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 September 2022
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| In: |
BMC cancer
Year: 2022, Volume: 22, Pages: 1-14 |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-022-10075-8 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12885-022-10075-8
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| Author Notes: | Tobias Hein, Peter H. Krammer and Heiko Weyd |
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| 520 | |a Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin core domain, present in all members of the Annexin family, becomes exposed on the apoptotic cell-surface and triggers tolerogenic signalling in phagocytes via the Dectin-1 receptor. Consequently, Annexins exposed on tumour cells upon cell death are expected to induce tolerance towards tumour antigens, inhibiting tumour rejection. | ||
| 650 | 4 | |a Annexins | |
| 650 | 4 | |a Apoptotic cells | |
| 650 | 4 | |a Immunosuppression | |
| 650 | 4 | |a Peripheral tolerance | |
| 650 | 4 | |a Tumour microenvironment | |
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