Molecular analysis of Annexin expression in cancer
Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin core domain, present in all members of the Annexin family, becomes exposed on the apoptotic cell-surface and triggers tolerogenic signalling in phagocytes via the D...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 September 2022
|
| In: |
BMC cancer
Year: 2022, Jahrgang: 22, Pages: 1-14 |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-022-10075-8 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12885-022-10075-8
|
| Verfasserangaben: | Tobias Hein, Peter H. Krammer and Heiko Weyd |
| Zusammenfassung: | Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin core domain, present in all members of the Annexin family, becomes exposed on the apoptotic cell-surface and triggers tolerogenic signalling in phagocytes via the Dectin-1 receptor. Consequently, Annexins exposed on tumour cells upon cell death are expected to induce tolerance towards tumour antigens, inhibiting tumour rejection. |
|---|---|
| Beschreibung: | Gesehen am 20.10.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-022-10075-8 |