Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease
The diagnostic procedures in patients with suspected fatty liver disease—with or without known alcohol consumption—should be standardized and generally accepted. We therefore present a guideline, summarizing the current concepts of etiology, diagnostic as well as differential diagnostic of patients...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 March 2011
|
| In: |
Virchows Archiv
Year: 2011, Jahrgang: 458, Heft: 5, Pages: 511-523 |
| ISSN: | 1432-2307 |
| DOI: | 10.1007/s00428-011-1066-1 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00428-011-1066-1
|
| Verfasserangaben: | Andrea Tannapfel, Helmut Denk, Hans-Peter Dienes, Cord Langner, Peter Schirmacher, Michael Trauner, Berenike Flott-Rahmel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1819534146 | ||
| 003 | DE-627 | ||
| 005 | 20230925150539.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221020s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00428-011-1066-1 |2 doi | |
| 035 | |a (DE-627)1819534146 | ||
| 035 | |a (DE-599)KXP1819534146 | ||
| 035 | |a (OCoLC)1389765549 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Tannapfel, Andrea |d 1966- |e VerfasserIn |0 (DE-588)122478460 |0 (DE-627)081968264 |0 (DE-576)183031857 |4 aut | |
| 245 | 1 | 0 | |a Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease |c Andrea Tannapfel, Helmut Denk, Hans-Peter Dienes, Cord Langner, Peter Schirmacher, Michael Trauner, Berenike Flott-Rahmel |
| 264 | 1 | |c 26 March 2011 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.10.2022 | ||
| 520 | |a The diagnostic procedures in patients with suspected fatty liver disease—with or without known alcohol consumption—should be standardized and generally accepted. We therefore present a guideline, summarizing the current concepts of etiology, diagnostic as well as differential diagnostic of patients with fatty liver disease. Alcoholic as well as and non-alcoholic fatty liver are characterised by lipid deposition in hepatocytes. The diagnosis of steatosis is made when lipid deposition exceeds 5% of hepatocytes, while involvement of more than 50% is called “fatty liver”. An additional inflammatory reaction leads to alcoholic (ASH) or non-alcoholic steatohepatitis (NASH). Steatohepatitis is present when both inflammatory infiltrates of mixed cells in the small liver lobules as well as liver cell injury in terms of ballooning can be detected. Liver biopsy represents the “golden standard” for confirming diagnosis and determining inflammatory activity and potential fibrosis of fatty liver disease. The differential diagnosis of ASH vs. NASH cannot be made on the basis of histological criteria alone. Steatosis, inflammatory changes and hepatocytic injury can be semiquantified as a “Brunt Score” or “NAS” (NAFLD activity score), providing the basis on which to decide whether or not steatohepatitis is present. People at increased risk of developing a fatty liver possess an increased risk of developing chemotherapy-associated steatohepatitis. Histologically, pediatric NASH differs from adult NASH and is often only clinically manifest through a mild if persistent elevation in transaminases. | ||
| 650 | 4 | |a Alcoholic steatohepatitis | |
| 650 | 4 | |a Ballooning | |
| 650 | 4 | |a Chemotherapy | |
| 650 | 4 | |a Cirrhosis | |
| 650 | 4 | |a Differential diagnosis | |
| 650 | 4 | |a Fibrosis | |
| 650 | 4 | |a Liver biopsy | |
| 650 | 4 | |a NASH in children | |
| 650 | 4 | |a Non-alcoholic steatohepatitis | |
| 650 | 4 | |a Scoring | |
| 700 | 1 | |a Denk, Helmut |d 1940- |e VerfasserIn |0 (DE-588)1028336047 |0 (DE-627)730585891 |0 (DE-576)375827900 |4 aut | |
| 700 | 1 | |a Dienes, Hans-Peter |d 1944- |e VerfasserIn |0 (DE-588)114614931X |0 (DE-627)1007709847 |0 (DE-576)180254197 |4 aut | |
| 700 | 1 | |a Langner, Cord |d 1962- |e VerfasserIn |0 (DE-588)11584225X |0 (DE-627)07750674X |0 (DE-576)290108330 |4 aut | |
| 700 | 1 | |a Schirmacher, Peter |d 1961- |e VerfasserIn |0 (DE-588)1020440112 |0 (DE-627)691221197 |0 (DE-576)360427448 |4 aut | |
| 700 | 1 | |a Trauner, Michael |d 1964- |e VerfasserIn |0 (DE-588)1141405369 |0 (DE-627)1000309215 |0 (DE-576)494386401 |4 aut | |
| 700 | 1 | |a Flott-Rahmel, Berenike |d 1959- |e VerfasserIn |0 (DE-588)1145679137 |0 (DE-627)1006866515 |0 (DE-576)167561820 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Virchows Archiv |d Berlin : Springer, 1847 |g 458(2011), 5, Seite 511-523 |h Online-Ressource |w (DE-627)254910645 |w (DE-600)1463276-7 |w (DE-576)074754416 |x 1432-2307 |7 nnas |a Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease |
| 773 | 1 | 8 | |g volume:458 |g year:2011 |g number:5 |g pages:511-523 |g extent:13 |a Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |a Tannapfel, Andrea, 1966 - |t Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease |d 2011 |w (DE-627)1632645823 |w (DE-576)365648175 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00428-011-1066-1 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221020 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1020440112 |a Schirmacher, Peter |m 1020440112:Schirmacher, Peter |d 910000 |d 912000 |e 910000PS1020440112 |e 912000PS1020440112 |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 999 | |a KXP-PPN1819534146 |e 4199578439 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease","title":"Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease"}],"recId":"1819534146","name":{"displayForm":["Andrea Tannapfel, Helmut Denk, Hans-Peter Dienes, Cord Langner, Peter Schirmacher, Michael Trauner, Berenike Flott-Rahmel"]},"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"26 March 2011"}],"person":[{"display":"Tannapfel, Andrea","given":"Andrea","family":"Tannapfel","role":"aut"},{"role":"aut","family":"Denk","display":"Denk, Helmut","given":"Helmut"},{"role":"aut","given":"Hans-Peter","display":"Dienes, Hans-Peter","family":"Dienes"},{"family":"Langner","given":"Cord","display":"Langner, Cord","role":"aut"},{"family":"Schirmacher","given":"Peter","display":"Schirmacher, Peter","role":"aut"},{"role":"aut","family":"Trauner","given":"Michael","display":"Trauner, Michael"},{"family":"Flott-Rahmel","display":"Flott-Rahmel, Berenike","given":"Berenike","role":"aut"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"part":{"extent":"13","issue":"5","year":"2011","pages":"511-523","text":"458(2011), 5, Seite 511-523","volume":"458"},"id":{"eki":["254910645"],"issn":["1432-2307"],"zdb":["1463276-7"]},"note":["Gesehen am 06.12.05"],"corporate":[{"role":"isb","display":"European Society of Pathology"}],"origin":[{"publisherPlace":"Berlin ; Heidelberg","dateIssuedKey":"1847","dateIssuedDisp":"1847-","publisher":"Springer"}],"title":[{"title":"Virchows Archiv","subtitle":"official journal of the European Society of Pathology","title_sort":"Virchows Archiv"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.1847 -"],"recId":"254910645","disp":"Histopathological diagnosis of non-alcoholic and alcoholic fatty liver diseaseVirchows Archiv","language":["eng"],"titleAlt":[{"title":"Archiv für pathologische Anatomie und Physiologie und für klinische Medicin"},{"title":"Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizin"},{"title":"Virchows Archiv / A"}]}],"note":["Gesehen am 20.10.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1819534146"],"doi":["10.1007/s00428-011-1066-1"]},"physDesc":[{"extent":"13 S."}]} | ||
| SRT | |a TANNAPFELAHISTOPATHO2620 | ||