Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants
Background: Though various neurohormonal systems are concurrently activated during birth, their biological effectors are not always easy to measure due to their short half-life in vivo, instability in biological samples, or very low concentrations. - Methods: Using a recently discovered chemilumines...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2, 2011
|
| In: |
Hormone research in paediatrics
Year: 2011, Jahrgang: 76, Heft: 4, Pages: 234-239 |
| ISSN: | 1663-2826 |
| DOI: | 10.1159/000329285 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000329285 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/329285 
|
| Verfasserangaben: | L. Koch, M.T. Dabek, D. Frommhold, J. Poeschl |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1819768597 | ||
| 003 | DE-627 | ||
| 005 | 20230710110020.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221024s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000329285 |2 doi | |
| 035 | |a (DE-627)1819768597 | ||
| 035 | |a (DE-599)KXP1819768597 | ||
| 035 | |a (OCoLC)1389764732 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Koch, Lutz |d 1973- |e VerfasserIn |0 (DE-588)1050055195 |0 (DE-627)783257201 |0 (DE-576)404355803 |4 aut | |
| 245 | 1 | 0 | |a Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants |c L. Koch, M.T. Dabek, D. Frommhold, J. Poeschl |
| 264 | 1 | |c September 2, 2011 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.10.2022 | ||
| 520 | |a Background: Though various neurohormonal systems are concurrently activated during birth, their biological effectors are not always easy to measure due to their short half-life in vivo, instability in biological samples, or very low concentrations. - Methods: Using a recently discovered chemiluminescence assay, we measured the stable precursor fragments mid-regional pro-atrial natriuretic peptide (MR-proANP), mid-regional pro-adrenomedullin (MR-proADM), C-terminal pro-endothelin-1 (CT-proET-1) and C-terminal pro-vasopressin (CT-proAVP or copeptin) immediately after birth in umbilical venous cord blood from 119 infants with a gestational age of 23-42 weeks and evaluated their possible functions. - Results: Cord blood levels of MR-proANP, MR- proADM, CT-proET-1, and CT-proAVP were considerably higher compared with normal adult levels. The CT-proAVP concentrations were 10-fold higher in term, and 70-fold higher in extremely preterm infants. MR-proANP showed 4-fold higher levels in term infants and 20-fold higher levels in extremely preterm infants. Levels of MR-proADM and CT-proET-1 were 2- to 3-fold higher in preterm and term infants. All four parameters showed significantly decreased values with increasing gestational age and a significant correlation between CT-proET-1 and MR-proADM. - Conclusion: Our results indicate that vasoactive and natriuretic mediators play a functionally relevant role in circulatory transition from fetal to neonatal life. | ||
| 700 | 1 | |a Dabek, Martin Thomas |d 1980- |e VerfasserIn |0 (DE-588)1013753747 |0 (DE-627)705094715 |0 (DE-576)347679021 |4 aut | |
| 700 | 1 | |a Frommhold, David |d 1974- |e VerfasserIn |0 (DE-588)128786787 |0 (DE-627)379685779 |0 (DE-576)297332643 |4 aut | |
| 700 | 1 | |a Pöschl, Johannes |e VerfasserIn |0 (DE-588)1021936847 |0 (DE-627)715839977 |0 (DE-576)36384757X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Hormone research in paediatrics |d Basel : Karger, 2010 |g 76(2011), 4, Seite 234-239 |h Online-Ressource |w (DE-627)619679905 |w (DE-600)2540224-9 |w (DE-576)319103889 |x 1663-2826 |7 nnas |a Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants |
| 773 | 1 | 8 | |g volume:76 |g year:2011 |g number:4 |g pages:234-239 |g extent:6 |a Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants |
| 856 | 4 | 0 | |u https://doi.org/10.1159/000329285 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.karger.com/Article/FullText/329285 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221024 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1021936847 |a Pöschl, Johannes |m 1021936847:Pöschl, Johannes |d 50000 |e 50000PP1021936847 |k 0/50000/ |p 4 |y j | ||
| 998 | |g 128786787 |a Frommhold, David |m 128786787:Frommhold, David |d 910000 |d 910500 |e 910000PF128786787 |e 910500PF128786787 |k 0/910000/ |k 1/910000/910500/ |p 3 | ||
| 998 | |g 1013753747 |a Dabek, Martin Thomas |m 1013753747:Dabek, Martin Thomas |d 910000 |d 910500 |e 910000PD1013753747 |e 910500PD1013753747 |k 0/910000/ |k 1/910000/910500/ |p 2 | ||
| 998 | |g 1050055195 |a Koch, Lutz |m 1050055195:Koch, Lutz |d 910000 |d 910500 |e 910000PK1050055195 |e 910500PK1050055195 |k 0/910000/ |k 1/910000/910500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1819768597 |e 4201275744 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 24.10.2022"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1819768597","title":[{"title_sort":"Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants","title":"Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infants"}],"person":[{"given":"Lutz","family":"Koch","role":"aut","roleDisplay":"VerfasserIn","display":"Koch, Lutz"},{"family":"Dabek","given":"Martin Thomas","display":"Dabek, Martin Thomas","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Frommhold, David","roleDisplay":"VerfasserIn","role":"aut","family":"Frommhold","given":"David"},{"roleDisplay":"VerfasserIn","display":"Pöschl, Johannes","role":"aut","family":"Pöschl","given":"Johannes"}],"physDesc":[{"extent":"6 S."}],"relHost":[{"title":[{"title":"Hormone research in paediatrics","subtitle":"from developmental endocrinology to clinical research","title_sort":"Hormone research in paediatrics"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Stable precursor fragments of vasoactive peptides in umbilical cord blood of term and preterm infantsHormone research in paediatrics","note":["Gesehen am 08.01.2019"],"recId":"619679905","language":["eng"],"pubHistory":["73.2010 -"],"part":{"pages":"234-239","issue":"4","year":"2011","extent":"6","text":"76(2011), 4, Seite 234-239","volume":"76"},"origin":[{"dateIssuedDisp":"2010-","dateIssuedKey":"2010","publisher":"Karger","publisherPlace":"Basel"}],"id":{"issn":["1663-2826"],"eki":["619679905"],"zdb":["2540224-9"]},"physDesc":[{"extent":"Online-Ressource"}]}],"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"September 2, 2011"}],"id":{"doi":["10.1159/000329285"],"eki":["1819768597"]},"name":{"displayForm":["L. Koch, M.T. Dabek, D. Frommhold, J. Poeschl"]}} | ||
| SRT | |a KOCHLUTZDASTABLEPREC2201 | ||