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Inverse electron-demand Diels-Alder reactions for the selective and efficient labeling of RNA

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We report the first example of RNA labeling based on inverse electron-demand Diels-Alder reactions. Both chemically synthesized and enzymatically transcribed RNAs were successfully modified with biotin or a fluorescent label. This approach works efficiently under mild conditions in water and does no...

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Bibliographische Detailangaben
Hauptverfasser: Schoch, Juliane (VerfasserIn) , Ameta, Sandeep (VerfasserIn) , Jäschke, Andres (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [2011]
In: Chemical communications
Year: 2011, Jahrgang: 47, Heft: 46, Pages: 12536-12537
ISSN:1364-548X
DOI:10.1039/C1CC15476A
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C1CC15476A
Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2011/cc/c1cc15476a
Volltext
Verfasserangaben:Juliane Schoch, Sandeep Ameta, Andres Jäschke
Beschreibung
Zusammenfassung:We report the first example of RNA labeling based on inverse electron-demand Diels-Alder reactions. Both chemically synthesized and enzymatically transcribed RNAs were successfully modified with biotin or a fluorescent label. This approach works efficiently under mild conditions in water and does not require transition metals.
Beschreibung:Gesehen am 25.10.2022
Beschreibung:Online Resource
ISSN:1364-548X
DOI:10.1039/C1CC15476A

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