Inverse electron-demand Diels-Alder reactions for the selective and efficient labeling of RNA
We report the first example of RNA labeling based on inverse electron-demand Diels-Alder reactions. Both chemically synthesized and enzymatically transcribed RNAs were successfully modified with biotin or a fluorescent label. This approach works efficiently under mild conditions in water and does no...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[2011]
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| In: |
Chemical communications
Year: 2011, Jahrgang: 47, Heft: 46, Pages: 12536-12537 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C1CC15476A |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/C1CC15476A Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2011/cc/c1cc15476a 
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| Verfasserangaben: | Juliane Schoch, Sandeep Ameta, Andres Jäschke |
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| 520 | |a We report the first example of RNA labeling based on inverse electron-demand Diels-Alder reactions. Both chemically synthesized and enzymatically transcribed RNAs were successfully modified with biotin or a fluorescent label. This approach works efficiently under mild conditions in water and does not require transition metals. | ||
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