eQTL set-based association analysis identifies novel susceptibility loci for Barrett esophagus and esophageal adenocarcinoma

Over 20 susceptibility single-nucleotide polymorphisms (SNP) have been identified for esophageal adenocarcinoma (EAC) and its precursor, Barrett esophagus (BE), explaining a small portion of heritability.Using genetic data from 4,323 BE and 4,116 EAC patients aggregated by international consortia in...

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Main Authors:	Wang, Xiaoyu (Author) , Gharahkhani, Puya (Author) , Levine, David M. (Author) , Fitzgerald, Rebecca C. (Author) , Gockel, Ines (Author) , Corley, Douglas A. (Author) , Risch, Harvey A. (Author) , Bernstein, Leslie (Author) , Chow, Wong-Ho (Author) , Onstad, Lynn (Author) , Shaheen, Nicholas J. (Author) , Lagergren, Jesper (Author) , Hardie, Laura J. (Author) , Wu, Anna H. (Author) , Pharoah, Paul (Author) , Liu, Geoffrey (Author) , Anderson, Lesley A. (Author) , Iyer, Prasad G. (Author) , Gammon, Marilie D. (Author) , Caldas, Carlos (Author) , Ye, Weimin (Author) , Barr, Hugh (Author) , Moayyedi, Paul (Author) , Harrison, Rebecca (Author) , Watson, R. G. Peter (Author) , Attwood, Stephen (Author) , Chegwidden, Laura (Author) , Love, Sharon B. (Author) , MacDonald, David (Author) , deCaestecker, John (Author) , Prenen, Hans (Author) , Ott, Katja (Author) , Moebus, Susanne (Author) , Venerito, Marino (Author) , Lang, Hauke (Author) , Mayershofer, Rupert Günther (Author) , Knapp, Michael (Author) , Veits, Lothar (Author) , Gerges, Christian (Author) , Weismüller, Josef (Author) , Reeh, Matthias (Author) , Nöthen, Markus Maria (Author) , Izbicki, Jakob R. (Author) , Manner, Hendrik (Author) , Neuhaus, Horst (Author) , Rösch, Thomas (Author) , Böhmer, Anne Christin (Author) , Hölscher, Arnulf H. (Author) , Anders, Mario (Author) , Pech, Oliver (Author) , Schumacher, Brigitte (Author) , Schmidt, Claudia (Author) , Schmidt, Thomas (Author) , Noder, Tania (Author) , Lorenz, Dietmar (Author) , Vieth, Michael (Author) , May, Andrea (Author) , Heß, Timo (Author) , Kreuser, Nicole (Author) , Becker, Jessica (Author) , Ell, Christian (Author) , Tomlinson, Ian (Author) , Palles, Claire (Author) , Jankowski, Janusz (Author) , Whiteman, David C. (Author) , MacGregor, Stuart (Author) , Schumacher, Johannes (Author) , Vaughan, Thomas L. (Author) , Buas, Matthew F. (Author) , Dai, James Y. (Author)
Format:	Article (Journal)
Language:	English
Published:	June 16, 2022
In:	Cancer epidemiology, biomarkers & prevention Year: 2022, Volume: 31, Issue: 9, Pages: 1735-1745
ISSN:	1538-7755
DOI:	10.1158/1055-9965.EPI-22-0096
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/1055-9965.EPI-22-0096 Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/cebp/article/31/9/1735/708731/eQTL-Set-Based-Association-Analysis-Identifies
Author Notes:	Xiaoyu Wang, Puya Gharahkhani, David M. Levine, Rebecca C. Fitzgerald, Ines Gockel, Douglas A. Corley, Harvey A. Risch, Leslie Bernstein, Wong-Ho Chow, Lynn Onstad, Nicholas J. Shaheen, Jesper Lagergren, Laura J. Hardie, Anna H. Wu, Paul D.P. Pharoah, Geoffrey Liu, Lesley A. Anderson, Prasad G. Iyer, Marilie D. Gammon, Carlos Caldas, Weimin Ye, Hugh Barr, Paul Moayyedi, Rebecca Harrison, R.G. Peter Watson, Stephen Attwood, Laura Chegwidden, Sharon B. Love, David MacDonald, John deCaestecker, Hans Prenen, Katja Ott, Susanne Moebus, Marino Venerito, Hauke Lang, Rupert Mayershofer, Michael Knapp, Lothar Veits, Christian Gerges, Josef Weismüller, Matthias Reeh, Markus M. Nöthen, Jakob R. Izbicki, Hendrik Manner, Horst Neuhaus, Thomas Rösch, Anne C. Böhmer, Arnulf H. Hölscher, Mario Anders, Oliver Pech, Brigitte Schumacher, Claudia Schmidt, Thomas Schmidt, Tania Noder, Dietmar Lorenz, Michael Vieth, Andrea May, Timo Hess, Nicole Kreuser, Jessica Becker, Christian Ell, Ian Tomlinson, Claire Palles, Janusz A. Jankowski, David C. Whiteman, Stuart MacGregor, Johannes Schumacher, Thomas L. Vaughan, Matthew F. Buas, and James Y. Dai