Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat
PURPOSE: To study the relative biological effectiveness (RBE) of carbon ion beams relative to X-rays for local tumor control in a syngeneic rat prostate tumor (Dunning subline R3327-AT1). - METHODS AND MATERIALS: A total of 198 animals with tumors in the distal thigh were treated with increasing sin...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
|
| In: |
International journal of radiation oncology, biology, physics
Year: 2011, Jahrgang: 79, Heft: 1, Pages: 239-246 |
| ISSN: | 1879-355X |
| DOI: | 10.1016/j.ijrobp.2010.07.1976 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2010.07.1976
|
| Verfasserangaben: | Peter Peschke, PH.D., Christian P. Karger, PH.D., Michael Scholz, PH.D., Jürgen Debus, M.D., PH.D., Peter E. Huber, M.D., PH.D. |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1819909492 | ||
| 003 | DE-627 | ||
| 005 | 20230710105122.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221025s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijrobp.2010.07.1976 |2 doi | |
| 035 | |a (DE-627)1819909492 | ||
| 035 | |a (DE-599)KXP1819909492 | ||
| 035 | |a (OCoLC)1389762321 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Peschke, Peter |e VerfasserIn |0 (DE-588)114228638X |0 (DE-627)1001681452 |0 (DE-576)494783443 |4 aut | |
| 245 | 1 | 0 | |a Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat |c Peter Peschke, PH.D., Christian P. Karger, PH.D., Michael Scholz, PH.D., Jürgen Debus, M.D., PH.D., Peter E. Huber, M.D., PH.D. |
| 264 | 1 | |c 2011 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 8 October 2010 | ||
| 500 | |a Gesehen am 25.10.2022 | ||
| 520 | |a PURPOSE: To study the relative biological effectiveness (RBE) of carbon ion beams relative to X-rays for local tumor control in a syngeneic rat prostate tumor (Dunning subline R3327-AT1). - METHODS AND MATERIALS: A total of 198 animals with tumors in the distal thigh were treated with increasing single and split doses of either (12)C ions or photons using a 20-mm spread-out Bragg peak. Endpoints of the study were local control (no tumor recurrence within 300 days) and volumetric changes after irradiation. The resulting values for D(50) (dose at 50% tumor control probability) were used to determine RBE values. - RESULTS: The D(50) values for single doses were 32.9 ± 0.9 Gy for (12)C ions and 75.7 ± 1.6 Gy for photons. The respective values for split doses were 38.0 ± 2.3 Gy and 90.6 ± 2.3 Gy. The corresponding RBE values were 2.30 ± 0.08 for single and 2.38 ± 0.16 for split doses. The most prominent side effects were dry and moist desquamation of the skin, which disappeared within weeks. - CONCLUSION: The study confirmed the effectiveness of carbon ion therapy for severely radioresistant tumors. For 1- and 2-fraction photon and (12)C ion radiation, we have established individual D(50) values for local tumor control as well as related RBE values. | ||
| 650 | 4 | |a Adenocarcinoma | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Carbon | |
| 650 | 4 | |a Cell Line, Tumor | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Photons | |
| 650 | 4 | |a Prostatic Neoplasms | |
| 650 | 4 | |a Radiation Injuries, Experimental | |
| 650 | 4 | |a Radiation Tolerance | |
| 650 | 4 | |a Radiation, Ionizing | |
| 650 | 4 | |a Radiodermatitis | |
| 650 | 4 | |a Rats | |
| 650 | 4 | |a Relative Biological Effectiveness | |
| 650 | 4 | |a Skin | |
| 650 | 4 | |a Tumor Burden | |
| 650 | 4 | |a Xenograft Model Antitumor Assays | |
| 700 | 1 | |a Karger, Christian |e VerfasserIn |0 (DE-588)1077113641 |0 (DE-627)836027280 |0 (DE-576)170866459 |4 aut | |
| 700 | 1 | |a Scholz, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Huber, Peter E. |d 1965- |e VerfasserIn |0 (DE-588)1074678869 |0 (DE-627)832350109 |0 (DE-576)442767803 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of radiation oncology, biology, physics |d Amsterdam [u.a.] : Elsevier Science, 1975 |g 79(2011), 1, Seite 239-246 |h Online-Ressource |w (DE-627)306659662 |w (DE-600)1500486-7 |w (DE-576)081986319 |x 1879-355X |7 nnas |a Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat |
| 773 | 1 | 8 | |g volume:79 |g year:2011 |g number:1 |g pages:239-246 |g extent:8 |a Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijrobp.2010.07.1976 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221025 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1074678869 |a Huber, Peter E. |m 1074678869:Huber, Peter E. |d 50000 |e 50000PH1074678869 |k 0/50000/ |p 5 |y j | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 4 | ||
| 998 | |g 1077113641 |a Karger, Christian |m 1077113641:Karger, Christian |d 50000 |e 50000PK1077113641 |k 0/50000/ |p 2 | ||
| 998 | |g 114228638X |a Peschke, Peter |m 114228638X:Peschke, Peter |p 1 |x j | ||
| 999 | |a KXP-PPN1819909492 |e 4201745686 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"disp":"Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the ratInternational journal of radiation oncology, biology, physics","origin":[{"dateIssuedDisp":"1975-","dateIssuedKey":"1975","publisherPlace":"Amsterdam [u.a.]","publisher":"Elsevier Science"}],"recId":"306659662","id":{"issn":["1879-355X"],"zdb":["1500486-7"],"eki":["306659662"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1975/76 -"],"note":["Gesehen am 15.01.20","Ungezählte Beil.: Supplement"],"language":["eng"],"part":{"volume":"79","text":"79(2011), 1, Seite 239-246","extent":"8","issue":"1","year":"2011","pages":"239-246"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"International journal of radiation oncology, biology, physics","title_sort":"International journal of radiation oncology, biology, physics","subtitle":"the official journal of the American Society for Therapeutic Radiology and Oncology"}]}],"title":[{"title_sort":"Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat","title":"Relative biological effectiveness of carbon ions for local tumor control of a radioresistant prostate carcinoma in the rat"}],"physDesc":[{"extent":"8 S."}],"language":["eng"],"note":["Available online 8 October 2010","Gesehen am 25.10.2022"],"person":[{"given":"Peter","family":"Peschke","role":"aut","display":"Peschke, Peter"},{"display":"Karger, Christian","family":"Karger","role":"aut","given":"Christian"},{"given":"Michael","display":"Scholz, Michael","family":"Scholz","role":"aut"},{"family":"Debus","role":"aut","display":"Debus, Jürgen","given":"Jürgen"},{"display":"Huber, Peter E.","family":"Huber","role":"aut","given":"Peter E."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1016/j.ijrobp.2010.07.1976"],"eki":["1819909492"]},"recId":"1819909492","origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"2011"}],"name":{"displayForm":["Peter Peschke, PH.D., Christian P. Karger, PH.D., Michael Scholz, PH.D., Jürgen Debus, M.D., PH.D., Peter E. Huber, M.D., PH.D."]}} | ||
| SRT | |a PESCHKEPETRELATIVEBI2011 | ||