Posttransplant sCD30 as a predictor of kidney graft outcome
Background. - Reliable markers for assessing the biological effect of immunosuppressive drugs and identification of transplant recipients at risk of developing rejection are not available. - Methods. - In a prospective multicenter study, we investigated whether posttransplant measurement of the T...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 27, 2011
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| In: |
Transplantation
Year: 2011, Volume: 91, Issue: 12, Pages: 1364-1369 |
| ISSN: | 1534-6080 |
| DOI: | 10.1097/TP.0b013e31821aba74 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/TP.0b013e31821aba74 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/transplantjournal/Fulltext/2011/06270/Posttransplant_sCD30_as_a_Predictor_of_Kidney.11.aspx 
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| Author Notes: | Caner Süsal, Bernd Döhler, Mahmoud Sadeghi, Kaija T. Salmela, Rolf Weimer, Martin Zeier, and Gerhard Opelz |
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| 520 | |a Background. - Reliable markers for assessing the biological effect of immunosuppressive drugs and identification of transplant recipients at risk of developing rejection are not available. - Methods. - In a prospective multicenter study, we investigated whether posttransplant measurement of the T-cell activation marker soluble CD30 (sCD30) can be used for estimating the risk of graft loss in kidney transplant recipients. Pre- and posttransplant sera of 2322 adult deceased-donor kidney recipients were tested for serum sCD30 content using a commercial enzyme-linked immunosorbent assay. - Results. - sCD30 decreased posttransplant and reached a nadir on day 30. Patients with a high sCD30 of more than or equal to 40 U/mL on day 30 showed a subsequent graft survival rate after 3 years of 78.3±4.1%, significantly lower than the 90.3±1.0% rate in recipients with a low sCD30 on day 30 of less than 40 U/mL (log-rank P<0.001; Cox hazard ratio 2.02, P<0.001). Although an association was found between pre- and posttransplant sCD30 levels, patients with high sCD30 on posttransplant day 30 demonstrated significantly lower 3-year graft survival irrespective of the pretransplant level. - Conclusions. - Our data suggest that posttransplant measurement of sCD30 on day 30 is a predictor of subsequent graft loss in kidney transplant recipients and that sCD30 may potentially serve as an indicator for adjustment of immunosuppressive medication. | ||
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