Cover Image

Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study

The prognostic value of MRD in large series of childhood T-ALL has not yet been established. Trial AIEOP-BFM-ALL 2000 introduced standardized quantitative assessment of MRD for stratification, based on immunoglobulin and TCR gene rearrangements as polymerase chain reaction targets: Patients were con...

Full description

Saved in:
Bibliographic Details
Main Authors: Schrappe, Martin (Author) , Valsecchi, Maria Grazia (Author) , Bartram, Claus R. (Author) , Schrauder, André (Author) , Panzer-Grümayer, Renate (Author) , Möricke, Anja (Author) , Parasole, Rosanna (Author) , Zimmermann, Martin (Author) , Dworzak, Michael (Author) , Buldini, Barbara (Author) , Reiter, Alfred (Author) , Basso, Giuseppe (Author) , Klingebiel, Thomas (Author) , Messina, Chiara (Author) , Ratei, Richard (Author) , Cazzaniga, Giovanni (Author) , Köhler, Rolf (Author) , Locatelli, Franco (Author) , Schäfer, Beat W. (Author) , Aricò, Maurizio (Author) , Welte, Karl (Author) , van Dongen, Jacques J.M. (Author) , Gadner, Helmut (Author) , Biondi, Andrea (Author) , Conter, Valentino (Author)
Format: Article (Journal)
Language:English
Published: August 25 2011
In: Blood
Year: 2011, Volume: 118, Issue: 8, Pages: 2077-2084
ISSN:1528-0020
DOI:10.1182/blood-2011-03-338707
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2011-03-338707
Get full text
Author Notes:Martin Schrappe, Maria Grazia Valsecchi, Claus R. Bartram, André Schrauder, Renate Panzer-Grümayer, Anja Möricke, Rosanna Parasole, Martin Zimmermann, Michael Dworzak, Barbara Buldini, Alfred Reiter, Giuseppe Basso, Thomas Klingebiel, Chiara Messina, Richard Ratei, Giovanni Cazzaniga, Rolf Koehler, Franco Locatelli, Beat W. Schäfer, Maurizio Aricò, Karl Welte, Jacques J.M. van Dongen, Helmut Gadner, Andrea Biondi, and Valentino Conter

MARC

LEADER 00000caa a2200000 c 4500
001 1820032663
003 DE-627
005 20230710104841.0
007 cr uuu---uuuuu
008 221026s2011 xx |||||o 00| ||eng c
024 7 |a 10.1182/blood-2011-03-338707  |2 doi 
035 |a (DE-627)1820032663 
035 |a (DE-599)KXP1820032663 
035 |a (OCoLC)1389761685 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Schrappe, Martin  |d 1958-  |e VerfasserIn  |0 (DE-588)130458805  |0 (DE-627)501601678  |0 (DE-576)298208423  |4 aut 
245 1 0 |a Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL  |b results of the AIEOP-BFM-ALL 2000 study  |c Martin Schrappe, Maria Grazia Valsecchi, Claus R. Bartram, André Schrauder, Renate Panzer-Grümayer, Anja Möricke, Rosanna Parasole, Martin Zimmermann, Michael Dworzak, Barbara Buldini, Alfred Reiter, Giuseppe Basso, Thomas Klingebiel, Chiara Messina, Richard Ratei, Giovanni Cazzaniga, Rolf Koehler, Franco Locatelli, Beat W. Schäfer, Maurizio Aricò, Karl Welte, Jacques J.M. van Dongen, Helmut Gadner, Andrea Biondi, and Valentino Conter 
264 1 |c August 25 2011 
300 |b Diagramme 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 26.10.2022 
520 |a The prognostic value of MRD in large series of childhood T-ALL has not yet been established. Trial AIEOP-BFM-ALL 2000 introduced standardized quantitative assessment of MRD for stratification, based on immunoglobulin and TCR gene rearrangements as polymerase chain reaction targets: Patients were considered MRD standard risk (MRD-SR) if MRD was negative at day 33 (time point 1 [TP1]) and day 78 (TP2), analyzed by at least 2 sensitive markers; MRD intermediate risk (MRD-IR) if positive either at day 33 or 78 and < 10−3 at day 78; and MRD high risk (MRD-HR) if ≥ 10−3 at day 78. A total of 464 patients with T-ALL were stratified by MRD: 16% of them were MRD-SR, 63% MRD-IR, and 21% MRD-HR. Their 7-year event-free-survival (SE) was 91.1% (3.5%), 80.6% (2.3%), and 49.8% (5.1%) (P < .001), respectively. Negativity of MRD at TP1 was the most favorable prognostic factor. An excellent outcome was also obtained in 32% of patients turning MRD negative only at TP2, indicating that early (TP1) MRD levels were irrelevant if MRD at TP2 was negative (48% of all patients). MRD ≥ 10−3 at TP2 constitutes the most important predictive factor for relapse in childhood T-ALL. The study is registered at http://www.clinicaltrials.gov; “Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia,” protocol identification #NCT00430118 for BFM and #NCT00613457 for AIEOP. 
700 1 |a Valsecchi, Maria Grazia  |e VerfasserIn  |4 aut 
700 1 |a Bartram, Claus R.  |d 1952-  |e VerfasserIn  |0 (DE-588)139758518  |0 (DE-627)613089502  |0 (DE-576)312997159  |4 aut 
700 1 |a Schrauder, André  |e VerfasserIn  |4 aut 
700 1 |a Panzer-Grümayer, Renate  |e VerfasserIn  |4 aut 
700 1 |a Möricke, Anja  |e VerfasserIn  |4 aut 
700 1 |a Parasole, Rosanna  |e VerfasserIn  |4 aut 
700 1 |a Zimmermann, Martin  |e VerfasserIn  |4 aut 
700 1 |a Dworzak, Michael  |e VerfasserIn  |4 aut 
700 1 |a Buldini, Barbara  |e VerfasserIn  |4 aut 
700 1 |a Reiter, Alfred  |e VerfasserIn  |4 aut 
700 1 |a Basso, Giuseppe  |e VerfasserIn  |4 aut 
700 1 |a Klingebiel, Thomas  |e VerfasserIn  |4 aut 
700 1 |a Messina, Chiara  |e VerfasserIn  |4 aut 
700 1 |a Ratei, Richard  |e VerfasserIn  |4 aut 
700 1 |a Cazzaniga, Giovanni  |e VerfasserIn  |4 aut 
700 1 |a Köhler, Rolf  |d 1966-  |e VerfasserIn  |0 (DE-588)12289751X  |0 (DE-627)082221545  |0 (DE-576)293468427  |4 aut 
700 1 |a Locatelli, Franco  |e VerfasserIn  |4 aut 
700 1 |a Schäfer, Beat W.  |e VerfasserIn  |4 aut 
700 1 |a Aricò, Maurizio  |e VerfasserIn  |4 aut 
700 1 |a Welte, Karl  |e VerfasserIn  |4 aut 
700 1 |a van Dongen, Jacques J.M.  |e VerfasserIn  |4 aut 
700 1 |a Gadner, Helmut  |e VerfasserIn  |4 aut 
700 1 |a Biondi, Andrea  |e VerfasserIn  |4 aut 
700 1 |a Conter, Valentino  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Blood  |d Washington, DC : American Society of Hematology, 1946  |g 118(2011), 8 vom: Aug., Seite 2077-2084  |h Online-Ressource  |w (DE-627)266886647  |w (DE-600)1468538-3  |w (DE-576)075961938  |x 1528-0020  |7 nnas  |a Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL results of the AIEOP-BFM-ALL 2000 study 
773 1 8 |g volume:118  |g year:2011  |g number:8  |g month:08  |g pages:2077-2084  |g extent:8  |a Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL results of the AIEOP-BFM-ALL 2000 study 
856 4 0 |u https://doi.org/10.1182/blood-2011-03-338707  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20221026 
993 |a Article 
994 |a 2011 
998 |g 12289751X  |a Köhler, Rolf  |m 12289751X:Köhler, Rolf  |d 910000  |d 911500  |e 910000PK12289751X  |e 911500PK12289751X  |k 0/910000/  |k 1/910000/911500/  |p 17 
998 |g 139758518  |a Bartram, Claus R.  |m 139758518:Bartram, Claus R.  |d 910000  |d 911500  |d 910000  |e 910000PB139758518  |e 911500PB139758518  |e 910000PB139758518  |k 0/910000/  |k 1/910000/911500/  |k 0/910000/  |p 3 
999 |a KXP-PPN1820032663  |e 4202104900 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Martin Schrappe, Maria Grazia Valsecchi, Claus R. Bartram, André Schrauder, Renate Panzer-Grümayer, Anja Möricke, Rosanna Parasole, Martin Zimmermann, Michael Dworzak, Barbara Buldini, Alfred Reiter, Giuseppe Basso, Thomas Klingebiel, Chiara Messina, Richard Ratei, Giovanni Cazzaniga, Rolf Koehler, Franco Locatelli, Beat W. Schäfer, Maurizio Aricò, Karl Welte, Jacques J.M. van Dongen, Helmut Gadner, Andrea Biondi, and Valentino Conter"]},"recId":"1820032663","id":{"doi":["10.1182/blood-2011-03-338707"],"eki":["1820032663"]},"origin":[{"dateIssuedDisp":"August 25 2011","dateIssuedKey":"2011"}],"language":["eng"],"physDesc":[{"extent":"8 S.","noteIll":"Diagramme"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"role":"aut","given":"Martin","family":"Schrappe","display":"Schrappe, Martin"},{"display":"Valsecchi, Maria Grazia","role":"aut","given":"Maria Grazia","family":"Valsecchi"},{"display":"Bartram, Claus R.","given":"Claus R.","role":"aut","family":"Bartram"},{"display":"Schrauder, André","family":"Schrauder","given":"André","role":"aut"},{"display":"Panzer-Grümayer, Renate","role":"aut","given":"Renate","family":"Panzer-Grümayer"},{"display":"Möricke, Anja","role":"aut","given":"Anja","family":"Möricke"},{"family":"Parasole","role":"aut","given":"Rosanna","display":"Parasole, Rosanna"},{"display":"Zimmermann, Martin","role":"aut","given":"Martin","family":"Zimmermann"},{"role":"aut","given":"Michael","family":"Dworzak","display":"Dworzak, Michael"},{"family":"Buldini","role":"aut","given":"Barbara","display":"Buldini, Barbara"},{"display":"Reiter, Alfred","family":"Reiter","role":"aut","given":"Alfred"},{"family":"Basso","given":"Giuseppe","role":"aut","display":"Basso, Giuseppe"},{"display":"Klingebiel, Thomas","given":"Thomas","role":"aut","family":"Klingebiel"},{"given":"Chiara","role":"aut","family":"Messina","display":"Messina, Chiara"},{"display":"Ratei, Richard","role":"aut","given":"Richard","family":"Ratei"},{"family":"Cazzaniga","role":"aut","given":"Giovanni","display":"Cazzaniga, Giovanni"},{"given":"Rolf","role":"aut","family":"Köhler","display":"Köhler, Rolf"},{"display":"Locatelli, Franco","family":"Locatelli","given":"Franco","role":"aut"},{"role":"aut","given":"Beat W.","family":"Schäfer","display":"Schäfer, Beat W."},{"display":"Aricò, Maurizio","role":"aut","given":"Maurizio","family":"Aricò"},{"display":"Welte, Karl","family":"Welte","role":"aut","given":"Karl"},{"display":"van Dongen, Jacques J.M.","given":"Jacques J.M.","role":"aut","family":"van Dongen"},{"display":"Gadner, Helmut","family":"Gadner","given":"Helmut","role":"aut"},{"display":"Biondi, Andrea","given":"Andrea","role":"aut","family":"Biondi"},{"family":"Conter","given":"Valentino","role":"aut","display":"Conter, Valentino"}],"title":[{"title_sort":"Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL","subtitle":"results of the AIEOP-BFM-ALL 2000 study","title":"Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL"}],"relHost":[{"pubHistory":["1.1946 -"],"titleAlt":[{"title":"Blood online"}],"note":["Gesehen am 21.04.2023"],"part":{"year":"2011","issue":"8","text":"118(2011), 8 vom: Aug., Seite 2077-2084","extent":"8","volume":"118","pages":"2077-2084"},"title":[{"subtitle":"journal of the American Society of Hematology","title":"Blood","title_sort":"Blood"}],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"display":"American Society of Hematology","role":"isb"}],"id":{"eki":["266886647"],"zdb":["1468538-3"],"issn":["1528-0020"]},"origin":[{"publisherPlace":"Washington, DC ; Philadelphia, Pa. ; Stanford, Calif.","publisher":"American Society of Hematology ; Saunders ; HighWire Press","dateIssuedKey":"1946","dateIssuedDisp":"1946-"}],"disp":"Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL results of the AIEOP-BFM-ALL 2000 studyBlood","recId":"266886647"}],"note":["Gesehen am 26.10.2022"]} 
SRT |a SCHRAPPEMALATEMRDRES2520 

Similar Items