A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis
According to the current consensus, murine neural stem cells (NSCs) apically contacting the lateral ventricle generate differentiated progenitors by rare asymmetric divisions or by relocating to the basal side of the ventricular–subventricular zone (V-SVZ). Both processes will ultimately lead to the...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 July 2022
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| In: |
EMBO reports
Year: 2022, Jahrgang: 23, Heft: 9, Pages: 1-20 |
| ISSN: | 1469-3178 |
| DOI: | 10.15252/embr.202154078 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.15252/embr.202154078 Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.15252/embr.202154078 
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| Verfasserangaben: | Katja Baur, Yomn Abdullah, Claudia Mandl, Gabriele Hölzl-Wenig, Yan Shi, Udo Edelkraut, Priti Khatri, Anna M Hagenston, Martin Irmler, Johannes Beckers & Francesca Ciccolini |
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| 520 | |a According to the current consensus, murine neural stem cells (NSCs) apically contacting the lateral ventricle generate differentiated progenitors by rare asymmetric divisions or by relocating to the basal side of the ventricular–subventricular zone (V-SVZ). Both processes will ultimately lead to the generation of adult-born olfactory bulb (OB) interneurons. In contrast to this view, we here find that adult-born OB interneurons largely derive from an additional NSC-type resident in the basal V-SVZ. | ||
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