Nucleosome mediated crosstalk between transcription factors at eukaryotic enhancers
A recent study of transcription regulation in Drosophila embryonic development revealed a complex non-monotonic dependence of gene expression on the distance between binding sites of repressor and activator proteins at the corresponding enhancer cis-regulatory modules (Fakhouri et al 2010 Mol. Syst....
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 June 2011
|
| In: |
Physical biology
Year: 2011, Jahrgang: 8, Heft: 4, Pages: 1-4 |
| ISSN: | 1478-3975 |
| DOI: | 10.1088/1478-3975/8/4/044001 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1088/1478-3975/8/4/044001 Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1088/1478-3975/8/4/044001 
|
| Verfasserangaben: | Vladimir B Teif and Karsten Rippe |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1820074641 | ||
| 003 | DE-627 | ||
| 005 | 20230710104710.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 221026s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1088/1478-3975/8/4/044001 |2 doi | |
| 035 | |a (DE-627)1820074641 | ||
| 035 | |a (DE-599)KXP1820074641 | ||
| 035 | |a (OCoLC)1389761781 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Teif, Vladimir |e VerfasserIn |0 (DE-588)1166808769 |0 (DE-627)1030675996 |0 (DE-576)510911242 |4 aut | |
| 245 | 1 | 0 | |a Nucleosome mediated crosstalk between transcription factors at eukaryotic enhancers |c Vladimir B Teif and Karsten Rippe |
| 264 | 1 | |c 10 June 2011 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.10.2022 | ||
| 520 | |a A recent study of transcription regulation in Drosophila embryonic development revealed a complex non-monotonic dependence of gene expression on the distance between binding sites of repressor and activator proteins at the corresponding enhancer cis-regulatory modules (Fakhouri et al 2010 Mol. Syst. Biol. 6 341). The repressor efficiency was high at small separations, low around 30 bp, reached a maximum at 50-60 bp, and decreased at larger distances to the activator binding sites. Here, we propose a straightforward explanation for the distance dependence of repressor activity by considering the effect of the presence of a nucleosome. Using a method that considers partial unwrapping of nucleosomal DNA from the histone octamer core, we calculated the dependence of activator binding on the repressor-activator distance and found a quantitative agreement with the distance dependence reported for the Drosophila enhancer element. In addition, the proposed model offers explanations for other distance-dependent effects at eukaryotic enhancers. | ||
| 700 | 1 | |a Rippe, Karsten |e VerfasserIn |0 (DE-588)102853261X |0 (DE-627)730885070 |0 (DE-576)168897989 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Physical biology |d Philadelphia, Pa. : IOP Publ., 2004 |g 8(2011), 4, Artikel-ID 044001, Seite 1-4 |h Online-Ressource |w (DE-627)377758701 |w (DE-600)2133216-2 |w (DE-576)260530360 |x 1478-3975 |7 nnas |a Nucleosome mediated crosstalk between transcription factors at eukaryotic enhancers |
| 773 | 1 | 8 | |g volume:8 |g year:2011 |g number:4 |g elocationid:044001 |g pages:1-4 |g extent:4 |a Nucleosome mediated crosstalk between transcription factors at eukaryotic enhancers |
| 856 | 4 | 0 | |u https://doi.org/10.1088/1478-3975/8/4/044001 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1088/1478-3975/8/4/044001 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20221026 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 102853261X |a Rippe, Karsten |m 102853261X:Rippe, Karsten |d 140000 |e 140000PR102853261X |k 0/140000/ |p 2 |y j | ||
| 999 | |a KXP-PPN1820074641 |e 4202290267 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"10 June 2011","dateIssuedKey":"2011"}],"recId":"1820074641","type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"id":{"eki":["377758701"],"issn":["1478-3975"],"zdb":["2133216-2"]},"physDesc":[{"extent":"Online-Ressource"}],"disp":"Nucleosome mediated crosstalk between transcription factors at eukaryotic enhancersPhysical biology","note":["Gesehen am 28.01.2019"],"origin":[{"publisher":"IOP Publ.","dateIssuedDisp":"2004-","dateIssuedKey":"2004","publisherPlace":"Philadelphia, Pa."}],"recId":"377758701","type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Physical biology","title":"Physical biology"}],"part":{"year":"2011","text":"8(2011), 4, Artikel-ID 044001, Seite 1-4","volume":"8","issue":"4","pages":"1-4","extent":"4"},"language":["eng"],"pubHistory":["1.2004 -"]}],"note":["Gesehen am 26.10.2022"],"physDesc":[{"extent":"4 S."}],"id":{"eki":["1820074641"],"doi":["10.1088/1478-3975/8/4/044001"]},"name":{"displayForm":["Vladimir B Teif and Karsten Rippe"]},"person":[{"family":"Teif","display":"Teif, Vladimir","given":"Vladimir","role":"aut"},{"given":"Karsten","role":"aut","display":"Rippe, Karsten","family":"Rippe"}],"language":["eng"],"title":[{"title_sort":"Nucleosome mediated crosstalk between transcription factors at eukaryotic enhancers","title":"Nucleosome mediated crosstalk between transcription factors at eukaryotic enhancers"}]} | ||
| SRT | |a TEIFVLADIMNUCLEOSOME1020 | ||