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Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

Mechanisms governing stress-induced hematopoietic progenitor cell mobilization are not fully deciphered. We report that during granulocyte colony-stimulating factor-induced mobilization c-Met expression and signaling are up-regulated on immature bone marrow progenitors. Interestingly, stromal cell-d...

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Hauptverfasser: Tesio, Melania (VerfasserIn) , Golan, Karin (VerfasserIn) , Corso, Simona (VerfasserIn) , Giordano, Silvia (VerfasserIn) , Schajnovitz, Amir (VerfasserIn) , Vagima, Yaron (VerfasserIn) , Shivtiel, Shoham (VerfasserIn) , Kalinkovich, Alexander (VerfasserIn) , Caione, Luisa (VerfasserIn) , Gammaitoni, Loretta (VerfasserIn) , Laurenti, Elisa (VerfasserIn) , Buß, Eike Christian (VerfasserIn) , Shezen, Elias (VerfasserIn) , Itkin, Tomer (VerfasserIn) , Kollet, Orit (VerfasserIn) , Petit, Isabelle (VerfasserIn) , Trumpp, Andreas (VerfasserIn) , Christensen, James (VerfasserIn) , Aglietta, Massimo (VerfasserIn) , Piacibello, Wanda (VerfasserIn) , Lapidot, Tsvee (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2011
In: Blood
Year: 2011, Jahrgang: 117, Heft: 2, Pages: 419-428
ISSN:1528-0020
DOI:10.1182/blood-2009-06-230359
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2009-06-230359
Volltext
Verfasserangaben:Melania Tesio, Karin Golan, Simona Corso, Silvia Giordano, Amir Schajnovitz, Yaron Vagima, Shoham Shivtiel, Alexander Kalinkovich, Luisa Caione, Loretta Gammaitoni, Elisa Laurenti, Eike C. Buss, Elias Shezen, Tomer Itkin, Orit Kollet, Isabelle Petit, Andreas Trumpp, James Christensen, Massimo Aglietta, Wanda Piacibello, and Tsvee Lapidot
Beschreibung
Zusammenfassung:Mechanisms governing stress-induced hematopoietic progenitor cell mobilization are not fully deciphered. We report that during granulocyte colony-stimulating factor-induced mobilization c-Met expression and signaling are up-regulated on immature bone marrow progenitors. Interestingly, stromal cell-derived factor 1/CXC chemokine receptor-4 signaling induced hepatocyte growth factor production and c-Met activation. We found that c-Met inhibition reduced mobilization of both immature progenitors and the more primitive Sca-1+/c-Kit+/Lin− cells and interfered with their enhanced chemotactic migration to stromal cell-derived factor 1. c-Met activation resulted in cellular accumulation of reactive oxygen species by mammalian target of rapamycin inhibition of Forkhead Box, subclass O3a. Blockage of mammalian target of rapamycin inhibition or reactive oxygen species signaling impaired c-Met-mediated mobilization. Our data show dynamic c-Met expression and function in the bone marrow and show that enhanced c-Met signaling is crucial to facilitate stress-induced mobilization of progenitor cells as part of host defense and repair mechanisms.
Beschreibung:Vorab online veröffentlicht am 28. Juni 2010
Gesehen am 27.10.2022
Beschreibung:Online Resource
ISSN:1528-0020
DOI:10.1182/blood-2009-06-230359

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