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FAP-specific signalling is an independent diagnostic approach in ACC and not a surrogate marker of MRI sequences

Background: Fibroblast Activation Protein (FAP) is a new target for positron emission tomography and computed tomography (PET/CT) imaging of epithelial tumours embedded in a fibrous stroma. Adenoid cystic carcinomas (ACCs) have shown elevated tracer uptake in 68Gallium (68Ga)-labelled FAPIs in previ...

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Hauptverfasser: Liew, Dawn (VerfasserIn) , Röhrich, Manuel (VerfasserIn) , Loi, Lisa (VerfasserIn) , Adeberg, Sebastian (VerfasserIn) , Syed, Mustafa (VerfasserIn) , Gutjahr, Ewgenija (VerfasserIn) , Schlemmer, Heinz-Peter (VerfasserIn) , Giesel, Frederik L. (VerfasserIn) , Bendszus, Martin (VerfasserIn) , Haberkorn, Uwe (VerfasserIn) , Paech, Daniel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 31 August 2022
In: Cancers
Year: 2022, Jahrgang: 14, Heft: 17, Pages: 1-12
ISSN:2072-6694
DOI:10.3390/cancers14174253
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers14174253
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/14/17/4253
Volltext
Verfasserangaben:Dawn P. Liew, Manuel Röhrich, Lisa Loi, Sebastian Adeberg, Mustafa Syed, Ewgenija Gutjahr, Heinz Peter Schlemmer, Frederik L. Giesel, Martin Bendszus, Uwe Haberkorn and Daniel Paech
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Zusammenfassung:Background: Fibroblast Activation Protein (FAP) is a new target for positron emission tomography and computed tomography (PET/CT) imaging of epithelial tumours embedded in a fibrous stroma. Adenoid cystic carcinomas (ACCs) have shown elevated tracer uptake in 68Gallium (68Ga)-labelled FAPIs in previous studies. The current gold standard for ACC imaging is contrast-enhanced (ce) MRI, where intertumoural heterogeneity leads to variable appearance on T1-weighted (T1w) and T2-weighted (T2w) images. In this retrospective analysis, we correlated 68Ga-FAPI PET signalling at three time points with ceT1w and T2w MRI signals to further characterise the significance of 68Ga-FAPI uptake in ACCs. Methods: Clinical PET/CT scans of 12 ACC patients were performed at 10, 60 and 180 min post i.v. administration of 68Ga-labelled-FAPI tracer molecules. 68Ga-PET- and corresponding MRI-scans were co-registered, and 3D volumetric segmentations were performed on ceT1w and T2w lesions of co-registered MRI slides. Signal intensity values of 68Ga-FAPI PET signalling and ceT1w/T2w MRI scans were analysed for their pixelwise correlation in each patient. Pooled estimates of the correlation coefficients were calculated using the Fisher z-transformation. Results: 68Ga-FAPI PET signals showed a very weak positive correlation with ceT1w values (pooled correlation 0.114, 0.147 and 0.162 at 10, 60 and 180 min) and a weak negative correlation with T2w values (pooled correlation −0.148, −0.121 and −0.225 at 10, 60 and 180 min). Individual r-values at 60 min ranged from −0.130 to 0.434 in ceT1w and from −0.466 to 0.637 in T2w MRI scans. Conclusion: There are only slight correlations between the intensity of 68Ga-FAPI PET signals and tumour appearance in ceT1w or T2w MRI scans, which underlines that 68Ga-FAPI PET signalling is not a surrogate marker of MRI sequences but an independent signal.
Beschreibung:Gesehen am 27.10.2022
Beschreibung:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers14174253

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