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Alterations of lipid metabolism in Wilson disease

Wilson disease (WD) is an inherited disorder of human copper metabolism, characterised by accumulation of copper predominantly in the liver and brain, leading to severe hepatic and neurological disease. Interesting findings in animal models of WD (Atp7b-/- and LEC rats) showed altered lipid metaboli...

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Bibliographic Details
Main Authors: Seeßle, Jessica (Author) , Gohdes, Marion Annina (Author) , Gotthardt, Daniel (Author) , Pfeiffenberger, Jan (Author) , Eckert, Nicola (Author) , Stremmel, Wolfgang (Author) , Reuner, Ulrike (Author) , Weiss, Karl Heinz (Author)
Format: Article (Journal)
Language:English
Published: 19 May 2011
In: Lipids in health and disease
Year: 2011, Volume: 10, Pages: 1-6
ISSN:1476-511X
DOI:10.1186/1476-511X-10-83
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1476-511X-10-83
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Author Notes:Jessica Seessle, Annina Gohdes, Daniel Nils Gotthardt, Jan Pfeiffenberger, Nicola Eckert, Wolfgang Stremmel, Ulrike Reuner and Karl Heinz Weiss
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Summary:Wilson disease (WD) is an inherited disorder of human copper metabolism, characterised by accumulation of copper predominantly in the liver and brain, leading to severe hepatic and neurological disease. Interesting findings in animal models of WD (Atp7b-/- and LEC rats) showed altered lipid metabolism with a decrease in the amount of triglycerides and cholesterol in the serum. However, serum lipid profile has not been investigated in large human WD patient cohorts to date.
Item Description:Gesehen am 31.10.2022
Physical Description:Online Resource
ISSN:1476-511X
DOI:10.1186/1476-511X-10-83

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