Concomitant cytotoxic effector differentiation of CD4+ and CD8+ T Cells in response to EBV-infected B cells
Most people infected by EBV acquire specific immunity, which then controls latent infection throughout their life. Immune surveillance of EBV-infected cells by cytotoxic CD4+ T cells has been recognized; however, the molecular mechanism of generating cytotoxic effector T cells of the CD4+ subset rem...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 August 2022
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| In: |
Cancers
Year: 2022, Jahrgang: 14, Heft: 17, Pages: 1-16 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers14174118 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers14174118 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/14/17/4118 
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| Verfasserangaben: | Yumi Tamura, Keita Yamane, Yohei Kawano, Lars Bullinger, Tristan Wirtz, Timm Weber, Sandrine Sander, Shun Ohki, Yasuo Kitajima, Satoshi Okada, Klaus Rajewsky and Tomoharu Yasuda |
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| 245 | 1 | 0 | |a Concomitant cytotoxic effector differentiation of CD4+ and CD8+ T Cells in response to EBV-infected B cells |c Yumi Tamura, Keita Yamane, Yohei Kawano, Lars Bullinger, Tristan Wirtz, Timm Weber, Sandrine Sander, Shun Ohki, Yasuo Kitajima, Satoshi Okada, Klaus Rajewsky and Tomoharu Yasuda |
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| 520 | |a Most people infected by EBV acquire specific immunity, which then controls latent infection throughout their life. Immune surveillance of EBV-infected cells by cytotoxic CD4+ T cells has been recognized; however, the molecular mechanism of generating cytotoxic effector T cells of the CD4+ subset remains poorly understood. Here we compared phenotypic features and the transcriptome of EBV-specific effector-memory CD4+ T cells and CD8+ T cells in mice and found that both T cell types show cytotoxicity and, to our surprise, widely similar gene expression patterns relating to cytotoxicity. Similar to cytotoxic CD8+ T cells, EBV-specific cytotoxic CD4+ T cells from human peripheral blood expressed T-bet, Granzyme B, and Perforin and upregulated the degranulation marker, CD107a, immediately after restimulation. Furthermore, T-bet expression in cytotoxic CD4+ T cells was highly correlated with Granzyme B and Perforin expression at the protein level. Thus, differentiation of EBV-specific cytotoxic CD4+ T cells is possibly controlled by mechanisms shared by cytotoxic CD8+ T cells. T-bet-mediated transcriptional regulation may explain the similarity of cytotoxic effector differentiation between CD4+ T cells and CD8+ T cells, implicating that this differentiation pathway may be directed by environmental input rather than T cell subset. | ||
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| 700 | 1 | |a Yamane, Keita |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kawano, Yohei |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Wirtz, Tristan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weber, Timm |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Rajewsky, Klaus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yasuda, Tomoharu |e VerfasserIn |4 aut | |
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