Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults
DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the E...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
07 September 2022
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| In: |
Nature Communications
Year: 2022, Volume: 13, Pages: 1-11 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-022-32893-x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-022-32893-x Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-022-32893-x 
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| Author Notes: | Xiangwei Li, Thomas Delerue, Ben Schöttker, Bernd Holleczek, Eva Grill, Annette Peters, Melanie Waldenberger, Barbara Thorand & Hermann Brenner |
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| 245 | 1 | 0 | |a Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults |c Xiangwei Li, Thomas Delerue, Ben Schöttker, Bernd Holleczek, Eva Grill, Annette Peters, Melanie Waldenberger, Barbara Thorand & Hermann Brenner |
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| 520 | |a DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci. Using LASSO regression, 20 CpGs are selected to derive a DNAm based algorithm for predicting frailty, the epigenetic frailty risk score (eFRS). The eFRS exhibits strong associations with frailty at baseline and after up to five-years of follow-up independently of established frailty risk factors. These associations are confirmed in another independent population-based cohort study, the KORA-Age study, conducted in older adults. In conclusion, we identify 65 CpGs as frailty-related loci, of which 20 CpGs are used to calculate the eFRS with predictive performance for frailty over long-term follow-up. | ||
| 650 | 4 | |a DNA methylation | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Geriatrics | |
| 650 | 4 | |a Predictive markers | |
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