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Randomized controlled phase I/II study to investigate immune stimulatory effects by low dose radiotherapy in primarily operable pancreatic cancer

The efficiencies of T cell based immunotherapies are affected by insufficient migration and activation of tumor specific effector T cells in the tumor. Accumulating evidence exists on the ability of ionizing radiation to modify the tumor microenvironment and generate inflammation. The aim of this ph...

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Bibliographische Detailangaben
Hauptverfasser: Timke, Carmen (VerfasserIn) , Schmitz-Winnenthal, Friedrich Hubertus (VerfasserIn) , Klug, Felix (VerfasserIn) , Röder, Falk (VerfasserIn) , Bonertz, Andreas (VerfasserIn) , Reißfelder, Christoph (VerfasserIn) , Rochet, Nathalie (VerfasserIn) , Koch, Moritz (VerfasserIn) , Tjaden, Christin (VerfasserIn) , Büchler, Markus W. (VerfasserIn) , Debus, Jürgen (VerfasserIn) , Werner, Jens (VerfasserIn) , Beckhove, Philipp (VerfasserIn) , Weitz, Jürgen (VerfasserIn) , Huber, Peter E. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 13 April 2011
In: BMC cancer
Year: 2011, Jahrgang: 11, Pages: 1-7
ISSN:1471-2407
DOI:10.1186/1471-2407-11-134
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2407-11-134
Volltext
Verfasserangaben:Carmen Timke, Hubertus Schmitz Winnenthal, Felix Klug, Falk FF Roeder, Andreas Bonertz, Christoph Reissfelder, Nathalie Rochet, Moritz Koch, Christine Tjaden, Markus W Buechler, Juergen Debus, Jens Werner, Philipp Beckhove, Jürgen Weitz and Peter E Huber
Beschreibung
Zusammenfassung:The efficiencies of T cell based immunotherapies are affected by insufficient migration and activation of tumor specific effector T cells in the tumor. Accumulating evidence exists on the ability of ionizing radiation to modify the tumor microenvironment and generate inflammation. The aim of this phase I/II clinical trial is to evaluate whether low dose single fraction radiotherapy can improve T cell associated antitumor immune response in patients with pancreatic cancer.
Beschreibung:Gesehen am 03.11.2022
Beschreibung:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-11-134

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