Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment
Purpose: Constitutive activation of epidermal growth factor receptor (EGFR) as a result of gene amplification, mutation, or overexpression of its ligands has been associated with response to EGFR targeting strategies. The role of these molecular mechanisms for the responsiveness of squamous cell car...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 31 2011
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| In: |
Clinical cancer research
Year: 2011, Volume: 17, Issue: 15, Pages: 5197-5204 |
| ISSN: | 1557-3265 |
| DOI: | 10.1158/1078-0432.CCR-10-3338 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-10-3338 |
| Author Notes: | Ingeborg Tinhofer, Konrad Klinghammer, Wilko Weichert, Maren Knödler, Albrecht Stenzinger, Thomas Gauler, Volker Budach, and Ulrich Keilholz |