Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment

Purpose: Constitutive activation of epidermal growth factor receptor (EGFR) as a result of gene amplification, mutation, or overexpression of its ligands has been associated with response to EGFR targeting strategies. The role of these molecular mechanisms for the responsiveness of squamous cell car...

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Main Authors: Tinhofer, Ingeborg (Author) , Klinghammer, Konrad (Author) , Weichert, Wilko (Author) , Knödler, Maren (Author) , Stenzinger, Albrecht (Author) , Gauler, Thomas (Author) , Budach, Volker (Author) , Keilholz, Ulrich (Author)
Format: Article (Journal)
Language:English
Published: July 31 2011
In: Clinical cancer research
Year: 2011, Volume: 17, Issue: 15, Pages: 5197-5204
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-10-3338
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-10-3338
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Author Notes:Ingeborg Tinhofer, Konrad Klinghammer, Wilko Weichert, Maren Knödler, Albrecht Stenzinger, Thomas Gauler, Volker Budach, and Ulrich Keilholz
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Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment by Tinhofer, Ingeborg (Author) , Klinghammer, Konrad (Author) , Weichert, Wilko (Author) , Knödler, Maren (Author) , Stenzinger, Albrecht (Author) , Gauler, Thomas (Author) , Budach, Volker (Author) , Keilholz, Ulrich (Author) ,


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