Post-translational timing mechanisms of the Drosophila circadian clock
Circadian clocks allow a temporal coordination and segregation of physiological, metabolic, and behavioural processes as well as their synchronization with the environmental cycles of day and night. Circadian regulation thereby provides a vital advantage, improving an organisms’ adaptation to its en...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 April 2011
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| In: |
FEBS letters
Year: 2011, Jahrgang: 585, Heft: 10, Pages: 1443-1449 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/j.febslet.2011.04.008 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.febslet.2011.04.008 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2011.04.008 
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| Verfasserangaben: | Frank Weber, Daniela Zorn, Christoph Rademacher, Hsiu-Cheng Hung |
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| 520 | |a Circadian clocks allow a temporal coordination and segregation of physiological, metabolic, and behavioural processes as well as their synchronization with the environmental cycles of day and night. Circadian regulation thereby provides a vital advantage, improving an organisms’ adaptation to its environment. The molecular clock can be synchronized with environmental cycles of day and night, but is able to maintain a self-sustained molecular oscillation also in the absence of environmental stimuli. Interlocked transcriptional-translational feedback loops were shown to form the basis of circadian clock function in all phyla from bacteria, fungi, plants, insects to humans. More recently post-translational regulation was identified to be equally important, if not sufficient for molecular clock function and accurate timing of circadian transcription. Here we review recent insights into post-translational timing mechanisms that control the circadian clock, with a particular focus on Drosophila. Analogous to transcriptional feedback regulation, circadian clock function in Drosophila appears to rely on inter-connected post-translational timers. Post-translational regulation of clock proteins illustrates mechanisms that allow a precise temporal control of transcription factors in general and of circadian transcription in particular. | ||
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| 650 | 4 | |a Nucleocytoplasmic transport | |
| 650 | 4 | |a Phosphorylation | |
| 650 | 4 | |a Post-translational regulation | |
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